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neuropeptide FF receptor 1
Symbol NPFFR1
Alt. symbols GPR147
Entrez 64106
HUGO 17425
OMIM 607448
RefSeq NM_022146
UniProt Q9GZQ6
Other data
Locus Chr. 10 q21-q22
neuropeptide FF receptor 2
Symbol NPFFR2
Alt. symbols GPR74
Entrez 10886
HUGO 4525
OMIM 607449
RefSeq NM_004885
UniProt Q9Y5X5
Other data
Locus Chr. 4 q21

The neuropeptide FF receptors[1] are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF.[2] These neuropeptides are thought to be involved in modulation of opioid receptor function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses.[3][4][5][6][7]





  • Neuropeptide AF
  • Neuropeptide FF



  1. ^ Parker RM, Copeland NG, Eyre HJ, Liu M, Gilbert DJ, Crawford J, Couzens M, Sutherland GR, Jenkins NA, Herzog H (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.  
  2. ^ Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.  
  3. ^ Yang HY, Iadarola MJ (May 2006). "Modulatory roles of the NPFF system in pain mechanisms at the spinal level". Peptides 27 (5): 943–52. doi:10.1016/j.peptides.2005.06.030. PMID 16443306.  
  4. ^ Roumy M, Lorenzo C, Mazères S, Bouchet S, Zajac JM, Mollereau C (March 2007). "Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity". The Journal of Biological Chemistry 282 (11): 8332–42. doi:10.1074/jbc.M606946200. PMID 17224450.  
  5. ^ Yang HY, Tao T, Iadarola MJ (February 2008). "Modulatory role of neuropeptide FF system in nociception and opiate analgesia". Neuropeptides 42 (1): 1–18. doi:10.1016/j.npep.2007.06.004. PMID 17854890.  
  6. ^ Betourne A, Familiades J, Lacassagne L, Halley H, Cazales M, Ducommun B, Lassalle JM, Zajac JM, Frances B (November 2008). "Decreased motivational properties of morphine in mouse models of cancerous- or inflammatory-chronic pain: implication of supraspinal neuropeptide FF(2) receptors". Neuroscience 157 (1): 12–21. doi:10.1016/j.neuroscience.2008.08.045. PMID 18804517.  
  7. ^ Cline MA, Mathews DS (2008). "Anoretic effects of neuropeptide FF are mediated via central mu and kappa subtypes of opioid receptors and receptor ligands". General and Comparative Endocrinology 159 (2-3): 125–9. doi:10.1016/j.ygcen.2008.09.001. PMID 18823989.  
  8. ^ Mollereau C, Mazarguil H, Marcus D, Quelven I, Kotani M, Lannoy V, Dumont Y, Quirion R, Detheux M, Parmentier M, Zajac JM (2002). "Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists". Eur. J. Pharmacol. 451 (3): 245–56. doi:10.1016/S0014-2999(02)02224-0. PMID 12242085.  
  9. ^ Fang Q, Guo J, He F, Peng YL, Chang M, Wang R (September 2006). "In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist". Peptides 27 (9): 2207–13. doi:10.1016/j.peptides.2006.04.002. PMID 16762456.  
  10. ^ Fang Q, Wang YQ, He F, Guo J, Guo J, Chen Q, Wang R (April 2008). "Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist". Regulatory Peptides 147 (1-3): 45–51. doi:10.1016/j.regpep.2007.12.007. PMID 18276024.  
  11. ^ Wang YQ, Guo J, Wang SB, Fang Q, He F, Wang R (July 2008). "Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice". Peptides 29 (7): 1183–90. doi:10.1016/j.peptides.2008.02.016. PMID 18406009.  

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