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Neuropeptide FF receptor 2
External IDs OMIM607449 MGI1860130 HomoloGene56982 IUPHAR: NPFF2 GeneCards: NPFFR2 Gene
Species Human Mouse
Entrez 10886 104443
Ensembl ENSG00000056291 ENSMUSG00000035528
UniProt Q9Y5X5 Q924N0
RefSeq (mRNA) NM_004885 XM_973847
RefSeq (protein) NP_004876 XP_978941
Location (UCSC) Chr 4:
73.12 - 73.23 Mb
Chr 5:
90.6 - 90.66 Mb
PubMed search [1] [2]

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.[1]


See also


External links

Further reading

  • Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.". Biochem. Biophys. Res. Commun. 256 (2): 352–6. doi:10.1006/bbrc.1999.0332. PMID 10079187.  
  • Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.  
  • Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.  
  • Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF.". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus.". Regul. Pept. 111 (1-3): 21–9. doi:10.1016/S0167-0115(02)00220-3. PMID 12609745.  
  • Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors.". Peptides 24 (12): 1947–54. doi:10.1016/j.peptides.2003.10.009. PMID 15127947.  
  • Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells.". Mol. Pharmacol. 67 (3): 965–75. doi:10.1124/mol.104.004614. PMID 15608144.  
  • Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216.  
  • Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression.". FEBS Lett. 580 (30): 6955–60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836.  
  • Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.". Am. J. Hum. Genet. 80 (6): 1115–24. doi:10.1086/518445. PMID 17503329.  


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