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Neuropeptide Y receptor Y1: Wikis

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Neuropeptide Y receptor Y1
Identifiers
Symbols NPY1R; NPYR
External IDs OMIM162641 MGI104963 HomoloGene700 IUPHAR: Y1 GeneCards: NPY1R Gene
RNA expression pattern
PBB GE NPY1R 205440 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4886 18166
Ensembl ENSG00000164128 ENSMUSG00000036437
UniProt P25929 Q3V1K5
RefSeq (mRNA) NM_000909 NM_010934
RefSeq (protein) NP_000900 NP_035064
Location (UCSC) Chr 4:
164.46 - 164.47 Mb
Chr 8:
69.63 - 69.64 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[1][2]

Contents

Selective Ligands

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Agonists

Antagonists

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

See also

References

  1. ^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (Apr 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". J Biol Chem 268 (9): 6703-7. PMID 8095935.  
  2. ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886.  

External links

Further reading

  • Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.  
  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.  
  • Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y.". Biopolymers 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.  
  • Larhammar D, Blomqvist AG, Yee F, et al. (1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.". J. Biol. Chem. 267 (16): 10935–8. PMID 1317848.  
  • Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems.". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMID 1321422.  
  • Rose PM, Fernandes P, Lynch JS, et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.". J. Biol. Chem. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.  
  • Gicquiaux H, Lecat S, Gaire M, et al. (2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.". J. Biol. Chem. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.  
  • Sheriff S, F Qureshy A, T Chance W, et al. (2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].". Peptides 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622.  
  • Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.  
  • Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.  
  • Cantó Soler MV, Gallo JE, Dodds RA, et al. (2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina.". Glia 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Berglund MM, Schober DA, Statnick MA, et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.  
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Körner M, Waser B, Reubi JC (2005). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia.". Clin. Cancer Res. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.  

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