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Neuropeptide Y receptor Y2
Symbols NPY2R;
External IDs OMIM162642 MGI108418 HomoloGene701 IUPHAR: Y2 GeneCards: NPY2R Gene
RNA expression pattern
PBB GE NPY2R 210730 s at tn.png
PBB GE NPY2R 210729 at tn.png
More reference expression data
Species Human Mouse
Entrez 4887 18167
Ensembl ENSG00000185149 ENSMUSG00000028004
UniProt P49146 Q8BWV1
RefSeq (mRNA) NM_000910 NM_008731
RefSeq (protein) NP_000901 NP_032757
Location (UCSC) Chr 4:
156.35 - 156.36 Mb
Chr 3:
82.62 - 82.63 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 2 is a protein that in humans is encoded by the NPY2R gene.[1][2]


Selective Ligands



  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • Neuropeptide Y fragment 13-36 (NPY2 selective agonist)
  • 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
  • Peptide YY
  • Peptide YY 3-36 fragment[3]


See also


  1. ^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Nov 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". J Biol Chem 270 (39): 22661-4. PMID 7559383.  
  2. ^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".  
  3. ^ Murphy KG, Dhillo WS, Bloom SR (December 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190.  

External links

Further reading

  • Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.  
  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.  
  • Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems.". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMID 1321422.  
  • Gerald C, Walker MW, Vaysse PJ, et al. (1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.". J. Biol. Chem. 270 (45): 26758–61. doi:10.1074/jbc.270.45.26758. PMID 7592910.  
  • Lynch JW, Lemos VS, Bucher B, et al. (1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.". J. Biol. Chem. 269 (11): 8226–33. PMID 8132547.  
  • Gehlert DR, Beavers LS, Johnson D, et al. (1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor.". Mol. Pharmacol. 49 (2): 224–8. PMID 8632753.  
  • Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMID 8643460.  
  • Ammar DA, Eadie DM, Wong DJ, et al. (1997). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.". Genomics 38 (3): 392–8. doi:10.1006/geno.1996.0642. PMID 8975716.  
  • Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.". J. Biol. Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.  
  • Caberlotto L, Fuxe K, Rimland JM, et al. (1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain.". Neuroscience 86 (1): 167–78. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752.  
  • Goumain M, Voisin T, Lorinet AM, et al. (2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.". Mol. Pharmacol. 60 (1): 124–34. PMID 11408607.  
  • Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.  
  • Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hyland NP, Sjöberg F, Tough IR, et al. (2004). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.". Br. J. Pharmacol. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMID 12813010.  
  • Hung CC, Pirie F, Luan J, et al. (2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.". Diabetes 53 (9): 2461–6. doi:10.2337/diabetes.53.9.2461. PMID 15331560.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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