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Neuropeptides B/W receptor 2
Symbols NPBWR2; GPR8
External IDs OMIM600731 HomoloGene48336 IUPHAR: NPBW2 GeneCards: NPBWR2 Gene
RNA expression pattern
PBB GE NPBWR2 221358 at tn.png
More reference expression data
Species Human Mouse
Entrez 2832 n/a
Ensembl ENSG00000125522 n/a
UniProt P48146 n/a
RefSeq (mRNA) NM_005286 n/a
RefSeq (protein) NP_005277 n/a
Location (UCSC) Chr 20:
62.21 - 62.21 Mb
PubMed search [1] n/a

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.[1]

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.[1]


See also


External links

Further reading

  • O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.". Genomics 28 (1): 84–91. doi:10.1006/geno.1995.1109. PMID 7590751.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.  
  • Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMID 12719537.  
  • Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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