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Neurotensin receptor 2
Identifiers
Symbols NTSR2; NTR2
External IDs OMIM605538 MGI108018 HomoloGene7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene
RNA expression pattern
PBB GE NTSR2 206899 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23620 18217
Ensembl ENSG00000169006 ENSMUSG00000020591
UniProt O95665 Q8VIF4
RefSeq (mRNA) XM_001129997 NM_008747
RefSeq (protein) XP_001129997 NP_032773
Location (UCSC) Chr 2:
11.72 - 11.73 Mb
Chr 12:
16.68 - 16.69 Mb
PubMed search [1] [2]

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]

Contents

See also

References

  1. ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (Jul 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Lett 386 (2-3): 91-4. PMID 8647296.  
  2. ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Feb 1999). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". Eur J Pharmacol 360 (2-3): 265-72. PMID 9851594.  
  3. ^ a b "Entrez Gene: NTSR2 neurotensin receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620.  

External links

Further reading

  • Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors.". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.  
  • Mazella J, Botto JM, Guillemare E, et al. (1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.". J. Neurosci. 16 (18): 5613–20. PMID 8795617.  
  • Ramez M, Bagot M, Nikolova M, et al. (2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes.". J. Invest. Dermatol. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.  
  • Martin S, Vincent JP, Mazella J (2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.". J. Cell. Sci. 115 (Pt 1): 165–73. PMID 11801734.  
  • Bourcier T, Rondeau N, Paquet S, et al. (2002). "Expression of neurotensin receptors in human corneal keratocytes.". Invest. Ophthalmol. Vis. Sci. 43 (6): 1765–71. PMID 12036977.  
  • Leyton J, Garcia-Marin L, Jensen RT, Moody TW (2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.". Eur. J. Pharmacol. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.  
  • Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Holst B, Holliday ND, Bach A, et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family.". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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