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Nicotinamide adenine dinucleotide phosphate
NADP+ phys.svg
CAS number 53-59-8 Yes check.svgY
PubChem 5884
Molecular formula C21H29N7O17P3
Molar mass 744.413
 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Nicotinamide adenine dinucleotide phosphate (NADP+, in older notation triphosphopyridine nucleotide, TPN) is used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

NADPH is the reduced form of NADP+. NADP+ differs from NAD+ by the presence in NADP+ of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety.

In plants

In chloroplasts, NADP+ is reduced by ferredoxin-NADP reductase in the last step of the electron chain of the light reactions of photosynthesis. The NADPH produced is then used as reducing power for the biosynthetic reactions in the Calvin cycle of photosynthesis.

In animals

The oxidative phase of the pentose phosphate pathway is the major source of NADPH in cells, producing approximately 60% of the NADPH required.

NADPH provides the reducing equivalents for biosynthetic reactions and for oxidation-reduction involved in protection against the toxicity of ROS (reactive oxygen species) i.e. the regeneration of reduced glutathione, known as GSH. NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis and fatty acid chain elongation.

It is the source of reducing equivalents for cytochrome 450 hydroxylation of aromatic compounds, steroids, alcohols, and drugs.

See also


Simple English

NADP (nicotinamide adenine dinucleotide phosphate) is a coenzyme that carries electrical energy used in cellular processes. When a hydrogen atom is added, NADP becomes charged and is renamed NADPH. NADP is used extensively during the Krebs (citric acid) cycle and during glycolysis and in the light-dependent reactions of photosynthesis.


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