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Nikethamide
Systematic (IUPAC) name
N,N-Diethyl-3-pyridinecarboxamide
Identifiers
CAS number 59-26-7
ATC code R07AB02
PubChem 5497
Chemical data
Formula C 10H14N2O 
Mol. mass 178.231
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 0.5 h
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-1900s as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now considered to be of no value for such purposes, and may in fact be dangerous.[1]

In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, as well as the phonemes of its common name.

Contents

Former medical use

Coramine was used by suspected serial killer Dr John Bodkin Adams when treating patient Gertrude Hullett, who he was suspected of murdering[2].

Theodor Morell, Adolf Hitler's personal physician, would inject the German ruler with Coramine when Hitler was unduly sedated with barbiturates. In addition, Morell would use Coramine as part of an all-purpose "tonic" for Hitler.[3]

Use in sports

In sports, nikethamide is listed by the World Anti-Doping Agency as a banned substance. Cyclists Jaime Huelamo and Aad van den Hoek were both caught using the drug at the 1972 Summer Olympics; at the time it was a permitted substance according to the International Cyclists Union but not the International Olympic Committee. When it was discovered that American sprinter and world champion Torri Edwards had used nikethamide, she was banned for two years. In 2005, however, WADA downgraded nikethamide so that one would only receive a maximum one-year ban. Official sources have stated that former Russian ice hockey player Alexei Cherepanov had been taking nikethamide and that it had been taken 3 hours prior to the game in which he died.

References

  1. ^ Martindale, The Extra Pharmacopoeia, 30th ed, p1229
  2. ^ Cullen, Pamela V., "A Stranger in Blood: The Case Files on Dr John Bodkin Adams", London, Elliott & Thompson, 2006, ISBN 1-904027-19-9
  3. ^ Doyle D (February 2005). "Adolf Hitler's medical care" (PDF). J. R. Coll. Physicians Edinb. 35 (1): 75–82. ISSN 1478-2715. OCLC 49953788. PMID 15825245. http://www.rcpe.ac.uk/journal/issue/journal_35_1/Hitler's_medical_care.pdf. Retrieved 2009-03-15.  

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