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Niobocene dichloride: Wikis

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Niobocene dichloride
Cp2NbCl2.png
IUPAC name
Other names Niobocene dichloride
Identifiers
CAS number 12793-14-5
RTECS number QU0400000
Properties
Molecular formula C10H1oCl2Nb
Molar mass 294 g/mol
Appearance brown solid
Melting point

dec.

Boiling point

dec.

Solubility in water soluble (hydrolysis)
Solubility in other solvents sparingly in chlorocarbons
Hazards
R-phrases 36/37/38
S-phrases 26-36
Related compounds
Related compounds Cp2TiCl2
Cp2MoCl2

Cp2VCl2

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Niobocene dichloride is the organometallic compound with the formula (C5H5)2NbCl2, abbreviated Cp2NbCl2. This paramagnetic brown solid is a starting reagent for the synthesis of other organoniobium compounds. The compound adopts a pseudotetrahedral structure with two cyclopentadienyl and two chloride substituents attached to the metal. A variety of similar compounds are known, including Cp2TiCl2.

It is prepared via a multistep reaction beginning with treatment of niobium pentachloride with cyclopentadienylsodium:[1]

NbCl5 + 6 NaC5H5 → 5 NaCl + (C5H5)4Nb + organic products
(C5H5)4Nb + 2 HCl + 0.5 O2) → [{C5H5)2NbCl}2O]Cl2 + 2 C5H6
2 HCl + [{(C5H5)2NbCl}2O]Cl 2 + SnCl2 → 2 (C5H5)2NbCl2 + SnCl4 + H2O

It was originally reported by Wilkinson.[2] It was investigated as a potential anti-cancer agent.[3]

References

  1. ^ C. R. Lucas, J. A. Labinger, J. Schwartz (1990). Robert J. Angelici. ed. "Dichlorobis(η5-Cyclopentadienyl)Niobium(IV)". Inorganic Syntheses (New York: J. Wiley & Sons) 28: 267–270. doi:10.1002/9780470132593.ch68. ISBN 0-471-52619-3.  
  2. ^ G. Wilkinson and J.G. Birmingham (1954). "Bis-cyclopentadienyl Compounds of Ti, Zr, V, Nb and Ta". Journal of the American Chemical Society 76 (17): 4281–4284. doi:10.1021/ja01646a008.  
  3. ^ Mokdsi, G.; Harding, M. M. (2001). "A1H NMR study of the Interaction of Antitumor Metallocenes with Glutathione". Journal of Inorganic Biochemistry 86: 611–616. doi:10.1016/S0162-0134(01)00221-5.  
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