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Nisoxetine: Wikis


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1 : 1 mixture (racemate)
Systematic (IUPAC) name
CAS number 57226-61-6
ATC code none
PubChem 4500
Chemical data
Formula C17H21NO2 
Mol. mass 271.354 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Nisoxetine (LY-94939) is a drug which inhibits the reuptake of norepinephrine (noradrenaline). It is a racemic compound with two isomers. Nisoxetine is not currently used in humans,[1] but was originally researched as an antidepressant and is now widely used in scientific research as a standard selective noradrenaline reuptake inhibitor.[2]


  1. ^ Kelwala S, Stanley M, Gershon S. History of antidepressants: successes and failures. Journal of Clinical Psychiatry. 1983 May;44(5 Pt 2):40-8.PMID 6222036
  2. ^ Graham D, Langer SZ. Advances in sodium-ion coupled biogenic amine transporters. Life Sciences. 1992;51(9):631-45.PMID 1501510


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