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Noxiptiline: Wikis

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Systematic (IUPAC) name
10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-dimethylamino)ethyl]oxime
CAS number 4985-15-3
ATC code  ?
PubChem 21087
ChemSpider 19832
Chemical data
Formula C19H22N2O
Mol. mass 294.39 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Noxiptiline (Agedal, Elronon, Nogedal), also known as dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. [1] [2] [3] [4] It has imipramine-like effects, [5] acting as a serotonin and norepinephrine reuptake inhibitor, among other pharmacological properties. [6][7] Of the TCAs, noxiptiline is one of the most effective, rivaling amitriptyline in clinical efficacy.[8][9]

See also


  1. ^ "Index nominum, international drug ... - Google Books".  
  2. ^ "Meyler's Side Effects of Psychiatric ... - Google Books".  
  3. ^ "Dictionary of organic compounds: Mes ... - Google Books".  
  4. ^ "Noxiptiline Hydrochloride: Martindale: The Complete Drug Reference".  
  5. ^ "Drug actions: basic principles and ... - Google Books".  
  6. ^ "Progress in drug research - Google Books".  
  7. ^ Barth N, Manns M, Muscholl E (1975). "Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart". Naunyn-Schmiedeberg's Archives of Pharmacology 288 (2-3): 215–31.  
  8. ^ Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]" (in Polish). Psychiatria Polska 25 (3-4): 13–8. PMID 1687987.  
  9. ^ Lingjaerde O, Asker T, Bugge A, et al. (January 1975). "Noxiptilin (Agedal)--a new tricyclic antidepressant with a faster onset of action? A double-blind, multicentre comparison with amitriptyline". Pharmakopsychiatrie, Neuro-Psychopharmakologie 8 (1): 26–35. PMID 788000.  

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