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Noxiptiline
Systematic (IUPAC) name
10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-dimethylamino)ethyl]oxime
Identifiers
CAS number 4985-15-3
ATC code  ?
PubChem 21087
ChemSpider 19832
Chemical data
Formula C19H22N2O
Mol. mass 294.39 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Noxiptiline (Agedal, Elronon, Nogedal), also known as dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. [1] [2] [3] [4] It has imipramine-like effects, [5] acting as a serotonin and norepinephrine reuptake inhibitor, among other pharmacological properties. [6][7] Of the TCAs, noxiptiline is one of the most effective, rivaling amitriptyline in clinical efficacy.[8][9]

See also

References

  1. ^ "Index nominum, international drug ... - Google Books". http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA753&dq=noxiptiline&as_brr=3&pg=PA753#v=onepage&q=noxiptiline&f=false.  
  2. ^ "Meyler's Side Effects of Psychiatric ... - Google Books". http://books.google.com/books?id=s0XYvuPVgaAC&lpg=PT44&dq=noxiptiline&as_brr=3&pg=PT44#v=onepage&q=noxiptiline&f=false.  
  3. ^ "Dictionary of organic compounds: Mes ... - Google Books". http://books.google.com/books?id=5S_uhYzKWisC&lpg=PA4868&dq=noxiptiline&as_brr=3&pg=PA4868#v=onepage&q=noxiptiline&f=false.  
  4. ^ "Noxiptiline Hydrochloride: Martindale: The Complete Drug Reference". http://www.medicinescomplete.com/mc/martindale/2009/2531-e.htm.  
  5. ^ "Drug actions: basic principles and ... - Google Books". http://books.google.com/books?id=IvN4mZxraMkC&lpg=PA723&dq=noxiptiline&as_brr=3&pg=PA127#v=onepage&q=noxiptiline&f=false.  
  6. ^ "Progress in drug research - Google Books". http://books.google.com/books?id=gwhdUGoO6KwC&lpg=PA80&dq=noxiptiline%20fluvoxamine&as_brr=3&pg=PA81#v=onepage&q=noxiptiline%20fluvoxamine&f=false.  
  7. ^ Barth N, Manns M, Muscholl E (1975). "Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart". Naunyn-Schmiedeberg's Archives of Pharmacology 288 (2-3): 215–31.  
  8. ^ Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]" (in Polish). Psychiatria Polska 25 (3-4): 13–8. PMID 1687987.  
  9. ^ Lingjaerde O, Asker T, Bugge A, et al. (January 1975). "Noxiptilin (Agedal)--a new tricyclic antidepressant with a faster onset of action? A double-blind, multicentre comparison with amitriptyline". Pharmakopsychiatrie, Neuro-Psychopharmakologie 8 (1): 26–35. PMID 788000.  







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