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Nuclear receptor co-repressor 1
Symbols NCOR1; KIAA1047; MGC104216; N-CoR; TRAC1; hCIT529I10; hN-CoR
External IDs OMIM600849 MGI1349717 HomoloGene38166 GeneCards: NCOR1 Gene
RNA expression pattern
PBB GE NCOR1 200854 at tn.png
PBB GE NCOR1 200855 at tn.png
PBB GE NCOR1 200856 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9611 20185
Ensembl ENSG00000141027 n/a
UniProt O75376 n/a
RefSeq (mRNA) XM_001133522 NM_011308
RefSeq (protein) XP_001133522 NP_035438
Location (UCSC) Chr 17:
15.88 - 16.06 Mb
PubMed search [1] [2]

The nuclear receptor co-repressor 1 (NCOR1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.[1][2]

NCOR1 is also sometimes referred to as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1).


External links


Nuclear receptor co-repressor 1 has been shown to interact with HDAC9,[3] CHD1,[4] HDAC7A,[5] MAP3K7IP2,[6] Glucocorticoid receptor,[7][8] MECP2,[9] Peroxisome proliferator-activated receptor alpha,[10] HEY2,[11] Histone deacetylase 5,[12][13] TBL1XR1,[14][15][12] TBL1X,[15][12][16][17] HDAC3,[14][15][18][5][12][16][19] ZBTB33,[14] Retinoic acid receptor alpha,[10][20] SAP30,[19][21] Androgen receptor,[22][23][24][25] Retinoic acid receptor gamma,[10] RUNX1T1,[26][27] HDAC4,[18][13] GPS2,[14][15][12] Calcitriol receptor[28][29] and Promyelocytic leukemia protein.[30]


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  2. ^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMID 9724795.  
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  4. ^ Tai, Helen H; Geisterfer Margit, Bell John C, Moniwa Mariko, Davie James R, Boucher Lorrie, McBurney Michael W (Aug. 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. (United States) 308 (1): 170–6. ISSN 0006-291X. PMID 12890497.  
  5. ^ a b Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. (United States) 276 (38): 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315.  
  6. ^ Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell (United States) 110 (1): 55–67. ISSN 0092-8674. PMID 12150997.  
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  8. ^ Schulz, Martin; Eggert Martin, Baniahmad Aria, Dostert Anja, Heinzel Thorsten, Renkawitz Rainer (Jul. 2002). "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. Chem. (United States) 277 (29): 26238–43. doi:10.1074/jbc.M203268200. ISSN 0021-9258. PMID 12011091.  
  9. ^ Kokura, K; Kaul S C, Wadhwa R, Nomura T, Khan M M, Shinagawa T, Yasukawa T, Colmenares C, Ishii S (Sep. 2001). "The Ski protein family is required for MeCP2-mediated transcriptional repression". J. Biol. Chem. (United States) 276 (36): 34115–21. doi:10.1074/jbc.M105747200. ISSN 0021-9258. PMID 11441023.  
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  11. ^ Iso, T; Sartorelli V, Poizat C, Iezzi S, Wu H Y, Chung G, Kedes L, Hamamori Y (Sep. 2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. (United States) 21 (17): 6080–9. ISSN 0270-7306. PMID 11486045.  
  12. ^ a b c d e Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell (United States) 9 (3): 611–23. ISSN 1097-2765. PMID 11931768.  
  13. ^ a b Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A (Jan. 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. (UNITED STATES) 14 (1): 45–54. ISSN 0890-9369. PMID 10640275.  
  14. ^ a b c d Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell (United States) 12 (3): 723–34. ISSN 1097-2765. PMID 14527417.  
  15. ^ a b c d Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. (England) 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMID 12628926.  
  16. ^ a b Li, J; Wang J, Wang J, Nawaz Z, Liu J M, Qin J, Wong J (Aug. 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. (ENGLAND) 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. ISSN 0261-4189. PMID 10944117.  
  17. ^ Guenther, M G; Lane W S, Fischle W, Verdin E, Lazar M A, Shiekhattar R (May. 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. (UNITED STATES) 14 (9): 1048–57. ISSN 0890-9369. PMID 10809664.  
  18. ^ a b Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell (United States) 9 (1): 45–57. ISSN 1097-2765. PMID 11804585.  
  19. ^ a b Underhill, C; Qutob M S, Yee S P, Torchia J (Dec. 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. (UNITED STATES) 275 (51): 40463–70. doi:10.1074/jbc.M007864200. ISSN 0021-9258. PMID 11013263.  
  20. ^ Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr. 1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood (UNITED STATES) 91 (8): 2634–42. ISSN 0006-4971. PMID 9531570.  
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  22. ^ Masiello, David; Chen Shao-Yong, Xu Youyuan, Verhoeven Manon C, Choi Eunis, Hollenberg Anthony N, Balk Steven P (Oct. 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol. (United States) 18 (10): 2388–401. doi:10.1210/me.2003-0436. ISSN 0888-8809. PMID 15256534.  
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Further reading

  • Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection.". Semin. Cell Dev. Biol. 10 (2): 215–25. doi:10.1006/scdb.1999.0303. PMID 10441075.  
  • Hörlein AJ, Näär AM, Heinzel T, et al. (1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.". Nature 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.  
  • Downes M, Burke LJ, Bailey PJ, Muscat GE (1997). "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.". Nucleic Acids Res. 24 (22): 4379–86. doi:10.1093/nar/24.22.4379. PMID 8948627.  
  • Tagami T, Madison LD, Nagaya T, Jameson JL (1997). "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone.". Mol. Cell. Biol. 17 (5): 2642–8. PMID 9111334.  
  • Zamir I, Dawson J, Lavinsky RM, et al. (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMID 9405624.  
  • Burke LJ, Downes M, Laudet V, Muscat GE (1998). "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.". Mol. Endocrinol. 12 (2): 248–62. doi:10.1210/me.12.2.248. PMID 9482666.  
  • Guidez F, Ivins S, Zhu J, et al. (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.". Blood 91 (8): 2634–42. PMID 9531570.  
  • Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.". Genes Dev. 12 (15): 2269–77. doi:10.1101/gad.12.15.2269. PMID 9694793.  
  • Laherty CD, Billin AN, Lavinsky RM, et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.". Mol. Cell 2 (1): 33–42. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189.  
  • Wang J, Hoshino T, Redner RL, et al. (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMID 9724795.  
  • Ordentlich P, Downes M, Xie W, et al. (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. doi:10.1073/pnas.96.6.2639. PMID 10077563.  
  • Dowell P, Ishmael JE, Avram D, et al. (1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein.". J. Biol. Chem. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.  
  • Boutell JM, Thomas P, Neal JW, et al. (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.". Hum. Mol. Genet. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647. PMID 10441327.  
  • Nagaya T, Chen KS, Fujieda M, et al. (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2.". Genomics 59 (3): 339–41. doi:10.1006/geno.1998.5694. PMID 10444336.  
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.  
  • Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.". Nature 402 (6757): 93–6. doi:10.1038/47069. PMID 10573424.  
  • Huang EY, Zhang J, Miska EA, et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.". Genes Dev. 14 (1): 45–54. PMID 10640275.  
  • Morohoshi F, Mitani S, Mitsuhashi N, et al. (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.". Gene 241 (2): 287–95. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.  
  • Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.". Oncogene 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.  


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