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Nuclear receptor coactivator 3

NCOA3 activation domain 1 (AD1) bound to a portion of CBP. PDB rendering based on 1kbh.
Available structures
1kbh
Identifiers
Symbols NCOA3; RAC3; ACTR; AIB-1; AIB1; CAGH16; CTG26; MGC141848; SRC-1; SRC3; TNRC14; TNRC16; TRAM-1; pCIP
External IDs OMIM601937 MGI1276535 HomoloGene4764 GeneCards: NCOA3 Gene
RNA expression pattern
PBB GE NCOA3 207700 s at tn.png
PBB GE NCOA3 209060 x at tn.png
PBB GE NCOA3 209062 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8202 17979
Ensembl ENSG00000124151 ENSMUSG00000027678
UniProt Q9Y6Q9 O09000
RefSeq (mRNA) NM_006534 NM_008679
RefSeq (protein) NP_006525 NP_032705
Location (UCSC) Chr 20:
45.56 - 45.72 Mb
Chr 2:
165.68 - 165.76 Mb
PubMed search [1] [2]

The nuclear receptor coactivator 3 also known as NCOA3 is a protein which in humans is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Contents

Function

NCOA3 is a transcriptional coactivator protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA3 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]

Interactions

Nuclear receptor coactivator 3 has been shown to interact with DDX17,[7] IKK2,[8] Androgen receptor,[9][10][11] CREB binding protein,[12][8] Glucocorticoid receptor,[13][14] Peroxisome proliferator-activated receptor gamma,[15] IKBKG,[8] Estrogen receptor alpha,[16][17][7] Estrogen receptor beta,[16][18] DDX5,[7] CHUK[8] and Retinoid X receptor alpha.[19][20]

References

  1. ^ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (August 1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science (journal) 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329.  
  2. ^ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (October 1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J. Biol. Chem. 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901.  
  3. ^ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329.  
  4. ^ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J Biol Chem 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901.  
  5. ^ "Study sheds new light on tamoxifen resistance". Cordis News. Cordis. 2008-11-13. http://cordis.europa.eu/fetch?CALLER=EN_NEWS&ACTION=D&SESSION=&RCN=30093. Retrieved 2008-11-14.  
  6. ^ Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS (December 2008). "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen". Nature 456 (7222): 663–6. doi:10.1038/nature07483. PMID 19005469.  
  7. ^ a b c Watanabe, M; Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (Mar. 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. (England) 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. ISSN 0261-4189. PMID 11250900.  
  8. ^ a b c d Wu, Ray-Chang; Qin Jun, Hashimoto Yoshihiro, Wong Jiemin, Xu Jianming, Tsai Sophia Y, Tsai Ming-Jer, O'Malley Bert W (May. 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Mol. Cell. Biol. (United States) 22 (10): 3549–61. ISSN 0270-7306. PMID 11971985.  
  9. ^ Tan, J A; Hall S H, Petrusz P, French F S (Sep. 2000). "Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator". Endocrinology (UNITED STATES) 141 (9): 3440–50. ISSN 0013-7227. PMID 10965917.  
  10. ^ Gnanapragasam, V J; Leung H Y, Pulimood A S, Neal D E, Robson C N (Dec. 2001). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer (Scotland) 85 (12): 1928–36. doi:10.1054/bjoc.2001.2179. ISSN 0007-0920. PMID 11747336.  
  11. ^ Wang, Qianben; Udayakumar T S, Vasaitis Tadas S, Brodie Angela M, Fondell Joseph D (Apr. 2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. (United States) 279 (17): 17319–28. doi:10.1074/jbc.M400970200. ISSN 0021-9258. PMID 14966121.  
  12. ^ Naltner, A; Wert S, Whitsett J A, Yan C (Dec. 2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung". Am. J. Physiol. Lung Cell Mol. Physiol. (UNITED STATES) 279 (6): L1066-74. ISSN 1040-0605. PMID 11076796.  
  13. ^ Hsiao, Pei-Wen; Fryer Christy J, Trotter Kevin W, Wang Weidong, Archer Trevor K (Sep. 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol. Cell. Biol. (United States) 23 (17): 6210–20. ISSN 0270-7306. PMID 12917342.  
  14. ^ Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (Apr. 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. (United States) 15 (4): 501–11. ISSN 0888-8809. PMID 11266503.  
  15. ^ Kodera, Y; Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (Oct. 2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. (UNITED STATES) 275 (43): 33201–4. doi:10.1074/jbc.C000517200. ISSN 0021-9258. PMID 10944516.  
  16. ^ a b Wong, C W; Komm B, Cheskis B J (Jun. 2001). "Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands". Biochemistry (United States) 40 (23): 6756–65. ISSN 0006-2960. PMID 11389589.  
  17. ^ Tikkanen, M K; Carter D J, Harris A M, Le H M, Azorsa D O, Meltzer P S, Murdoch F E (Nov. 2000). "Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (23): 12536–40. doi:10.1073/pnas.220427297. ISSN 0027-8424. PMID 11050174.  
  18. ^ Leo, C; Li H, Chen J D (Feb. 2000). "Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3". J. Biol. Chem. (UNITED STATES) 275 (8): 5976–82. ISSN 0021-9258. PMID 10681591.  
  19. ^ Chen, H; Lin R J, Schiltz R L, Chakravarti D, Nash A, Nagy L, Privalsky M L, Nakatani Y, Evans R M (Aug. 1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell (UNITED STATES) 90 (3): 569–80. ISSN 0092-8674. PMID 9267036.  
  20. ^ Lee, Wen-yi; Noy Noa (Feb. 2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry (United States) 41 (8): 2500–8. ISSN 0006-2960. PMID 11851396.  

External links

Further reading

  • Liao L, Kuang SQ, Yuan Y, et al. (2003). "Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1.". J. Steroid Biochem. Mol. Biol. 83 (1-5): 3–14. doi:10.1016/S0960-0760(02)00254-6. PMID 12650696.  
  • Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.". Mol. Cell. Biol. 15 (7): 3479–86. PMID 7791754.  
  • Guan XY, Xu J, Anzick SL, et al. (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer.". Cancer Res. 56 (15): 3446–50. PMID 8758910.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980.  
  • Li H, Gomes PJ, Chen JD (1997). "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8479–84. doi:10.1073/pnas.94.16.8479. PMID 9238002.  
  • Anzick SL, Kononen J, Walker RL, et al. (1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.". Science 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329.  
  • Chen H, Lin RJ, Schiltz RL, et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.". Cell 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. PMID 9267036.  
  • Takeshita A, Cardona GR, Koibuchi N, et al. (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.". J. Biol. Chem. 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901.  
  • Korzus E, Torchia J, Rose DW, et al. (1998). "Transcription factor-specific requirements for coactivators and their acetyltransferase functions.". Science 279 (5351): 703–7. doi:10.1126/science.279.5351.703. PMID 9445475.  
  • Shirazi SK, Bober MA, Coetzee GA (1998). "Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene).". Clin. Genet. 54 (1): 102–3. PMID 9727751.  
  • Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.". J. Biol. Chem. 273 (47): 30847–50. doi:10.1074/jbc.273.47.30847. PMID 9812974.  
  • Zwijsen RM, Buckle RS, Hijmans EM, et al. (1999). "Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.". Genes Dev. 12 (22): 3488–98. doi:10.1101/gad.12.22.3488. PMID 9832502.  
  • Chen H, Lin RJ, Xie W, et al. (1999). "Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.". Cell 98 (5): 675–86. doi:10.1016/S0092-8674(00)80054-9. PMID 10490106.  
  • Ebisawa T, Tada K, Kitajima I, et al. (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.". J. Cell. Sci. 112 ( Pt 20): 3519–27. PMID 10504300.  
  • Xie W, Hong H, Yang NN, et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2.". Mol. Endocrinol. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588.  
  • Pao GM, Janknecht R, Ruffner H, et al. (2000). "CBP/p300 interact with and function as transcriptional coactivators of BRCA1.". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1020–5. doi:10.1073/pnas.97.3.1020. PMID 10655477.  
  • Leo C, Li H, Chen JD (2000). "Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3.". J. Biol. Chem. 275 (8): 5976–82. doi:10.1074/jbc.275.8.5976. PMID 10681591.  
  • Font de Mora J, Brown M (2000). "AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor.". Mol. Cell. Biol. 20 (14): 5041–7. doi:10.1128/MCB.20.14.5041-5047.2000. PMID 10866661.  
  • Tan JA, Hall SH, Petrusz P, French FS (2000). "Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator.". Endocrinology 141 (9): 3440–50. doi:10.1210/en.141.9.3440. PMID 10965917.  
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