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Nuclear receptor related 1 protein: Wikis


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From Wikipedia, the free encyclopedia

Nuclear receptor subfamily 4, group A, member 2

PDB rendering based on 1cit.
Available structures
1cit, 1ovl
Symbols NR4A2; RNR1; HZF-3; NOT; NURR1; TINUR
External IDs OMIM601828 MGI1352456 HomoloGene4509 GeneCards: NR4A2 Gene
RNA expression pattern
PBB GE NR4A2 216248 s at tn.png
PBB GE NR4A2 204621 s at tn.png
PBB GE NR4A2 204622 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4929 18227
Ensembl ENSG00000153234 ENSMUSG00000026826
UniProt P43354 Q3TYI4
RefSeq (mRNA) NM_006186 NM_013613
RefSeq (protein) NP_006177 NP_038641
Location (UCSC) Chr 2:
156.89 - 156.9 Mb
Chr 2:
56.92 - 56.94 Mb
PubMed search [1] [2]

The Nuclear receptor related 1 (NURR1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR4A2 gene (nuclear receptor subfamily 4, group A, member 2).[1]

NURR1 plays a key role in the maintenance of the dopaminergic system of the brain.[2] Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.[3]



Nuclear receptor related 1 protein has been shown to interact with Retinoic acid receptor alpha[4] and Retinoic acid receptor beta.[4]


  1. ^ Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T (1995). "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line". J. Immunol. 154 (8): 3871–9. PMID 7706727.  
  2. ^ Sacchetti P, Carpentier R, Ségard P, Olivé-Cren C, Lefebvre P (2006). "Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1". Nucleic Acids Res. 34 (19): 5515–27. doi:10.1093/nar/gkl712. PMID 17020917.  
  3. ^ "Entrez Gene: NR4A2 nuclear receptor subfamily 4, group A, member 2".  
  4. ^ a b Perlmann, T; Jansson L (Apr. 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.  

Further reading

  • Le W, Appel SH (2004). "Mutant genes responsible for Parkinson's disease.". Current opinion in pharmacology 4 (1): 79–84. doi:10.1016/j.coph.2003.09.005. PMID 15018843.  
  • Wedler B, Wüstenberg PW, Naumann G (1976). "[Treatment of hypertonus in diabetes mellitus]". Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete 30 (13): 437–42. PMID 4929.  
  • Perlmann T, Jansson L (1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.". Genes Dev. 9 (7): 769–82. doi:10.1101/gad.9.7.769. PMID 7705655.  
  • Okabe T, Takayanagi R, Imasaki K, et al. (1995). "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.". J. Immunol. 154 (8): 3871–9. PMID 7706727.  
  • Forman BM, Umesono K, Chen J, Evans RM (1995). "Unique response pathways are established by allosteric interactions among nuclear hormone receptors.". Cell 81 (4): 541–50. doi:10.1016/0092-8674(95)90075-6. PMID 7758108.  
  • Mages HW, Rilke O, Bravo R, et al. (1995). "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.". Mol. Endocrinol. 8 (11): 1583–91. doi:10.1210/me.8.11.1583. PMID 7877627.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Torii T, Kawarai T, Nakamura S, Kawakami H (1999). "Organization of the human orphan nuclear receptor Nurr1 gene.". Gene 230 (2): 225–32. doi:10.1016/S0378-1119(99)00064-5. PMID 10216261.  
  • Ichinose H, Ohye T, Suzuki T, et al. (1999). "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs.". Gene 230 (2): 233–9. doi:10.1016/S0378-1119(99)00065-7. PMID 10216262.  
  • Chen YH, Tsai MT, Shaw CK, Chen CH (2002). "Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients.". Am. J. Med. Genet. 105 (8): 753–7. doi:10.1002/ajmg.10036. PMID 11803525.  
  • Ishiguro H, Okubo Y, Ohtsuki T, et al. (2002). "Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence.". Am. J. Med. Genet. 114 (1): 15–23. PMID 11840500.  
  • McEvoy AN, Murphy EA, Ponnio T, et al. (2002). "Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5'-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue.". J. Immunol. 168 (6): 2979–87. PMID 11884470.  
  • Xu PY, Liang R, Jankovic J, et al. (2002). "Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease.". Neurology 58 (6): 881–4. PMID 11914402.  
  • Bannon MJ, Pruetz B, Manning-Bog AB, et al. (2002). "Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6382–5. doi:10.1073/pnas.092654299. PMID 11959923.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Le WD, Xu P, Jankovic J, et al. (2003). "Mutations in NR4A2 associated with familial Parkinson disease.". Nat. Genet. 33 (1): 85–9. doi:10.1038/ng1066. PMID 12496759.  
  • Satoh J, Kuroda Y (2003). "The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines.". Neuropathology : official journal of the Japanese Society of Neuropathology 22 (4): 219–32. PMID 12564761.  
  • Iwayama-Shigeno Y, Yamada K, Toyota T, et al. (2003). "Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 118 (1): 20–4. doi:10.1002/ajmg.b.10053. PMID 12627459.  
  • Kim KS, Kim CH, Hwang DY, et al. (2003). "Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner.". J. Neurochem. 85 (3): 622–34. PMID 12694388.  

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