The Full Wiki

More info on O-Arachidonoylethanolamine

O-Arachidonoylethanolamine: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

(Redirected to Virodhamine article)

From Wikipedia, the free encyclopedia

Virodhamine
Virodhamine.png
IUPAC name
Other names O-Arachidonoyl ethanolamine
Identifiers
CAS number 443129-35-9
PubChem 5712057
SMILES
Properties
Molecular formula C22H37NO2
Molar mass 347.53468
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Virodhamine (O-arachidonoyl ethanolamine) is an endocannabinoid and a nonclassic eicosanoid, derived from arachidonic acid. O-Arachidonoyl ethanolamine is arachidonic acid and ethanolamine joined by an ester linkage, the opposite of the amide linkage found in anandamide. Based on this opposite orientation, the molecule was named virodhamine from the Sanskrit word virodha, which means opposition. It acts as an antagonist of the CB1 receptor and agonist of the CB2 receptor. Concentrations of virodhamine in the human hippocampus are similar to anandamide, but they were 2- to 9-fold higher in peripheral tissues that express CB2. Virodhamine lowers body temperature in mice, demonstrating cannabinoid activity in vivo.[1]

See also

References

  1. ^ Porter AC, Sauer JM, Knierman MD, et al. (2002). "Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor". J. Pharmacol. Exp. Ther. 301 (3): 1020–4. doi:10.1124/jpet.301.3.1020. PMID 12023533. http://jpet.aspetjournals.org/cgi/reprint/301/3/1020. Retrieved 2007-10-31.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message