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ORG-37,684
Systematic (IUPAC) name
(3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine
Identifiers
CAS number  ?
ATC code  ?
PubChem 9794656
Chemical data
Formula C 14H19NO2  
Mol. mass 233.305 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes  ?

ORG-37,684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

References

  1. ^ Adams, D.; Duncton, M. (2001). "EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684". Synthetic Communications 31: 2029. doi:10.1081/SCC-100104420.   edit
  2. ^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004;370:114-123. PMID 15322733
  3. ^ Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in Neuropsychopharmacology and Biological Psychiatry. 2002 Apr;26(3):441-9. PMID 11999893
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