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Olopatadine
Systematic (IUPAC) name
{(11Z)-11-[3-(dimethylamino)propylidene]-6,11-
dihydrodibenzo[b,e]oxepin-2-yl}acetic acid
Identifiers
CAS number 113806-05-6
ATC code S01GX09 R01AC08
PubChem 5281071
DrugBank APRD00310
Chemical data
Formula C 21H23NO3  
Mol. mass 337.412 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes Ophthalmic, intranasal, oral
 Yes check.svgY(what is this?)  (verify)

Olopatadine hydrochloride is an antihistamine (as well as anticholinergic) and mast cell stabilizer, sold as a prescription eye drop (0.2% solution, trademark Pataday (or Patanol S in some countries), manufactured by Alcon). It is used to treat itching associated with allergic conjunctivitis (eye allergies). Olopatadine hydrochloride 0.1% is sold as trademark Patanol (or Opatanol in some countries). A nasal spray formulation is sold as trademark Patanase, which was approved by the FDA on April 15, 2008.[1] It is also available as an oral tablet in Japan under the tradename Allelock, manufactured by Kyowa Hakko Kogyo.[2]

It should not be used to treat irritation caused by contact lenses. The usual dose for trademark Pataday is 1 drop in each affected eye once a day. The usual dose for trademark Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses.

Its side effects may include headaches (7% of occurrence) burning and stinging (5%), dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, asthenia, cold syndrome, pharyngitis, rhinitis, sinusitis, and taste perversion.

Olopatadine was developed by Kyowa Hakko Kogyo.[3]

References

  1. ^ Drugs.com, Alcon's Patanase Nasal Spray Approved by FDA for Treatment of Nasal Allergy Symptoms
  2. ^ Kyowa Hakko Kogyo Co., Ltd. (2007). "ALLELOCK Tablets 2.5 & ALLELOCK Tablets 5 (English)" (PDF). http://www.e-search.ne.jp/~jpr/PDF/KYOWA08.PDF. Retrieved 2008-08-10.  
  3. ^ Kyowa Hakko Kogyo Co., Ltd. (2002). "Company History". Company Information. Kyowa Hakko Kogyo Co., Ltd.. http://www.kyowa.co.jp/eng/company/iyaku/iyaku.htm. Retrieved 10 August 2008.  

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