Oogenesis: Wikis


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Oogenesis or oögenesis (pronounced /ˌoʊ.əˈdʒɛnɨsɪs/[1]) is the creation of an ovum (egg cell). It is the female equivalent of the male process of gametogenesis. It involves the development of the various stages of the immature ovum.


Oogenesis in mammals

Diagram showing the reduction in number of the chromosomes in the process of maturation of the ovum.

In mammals, the first part of oogenesis starts in the germinal epithelium, which gives rise to the development of ovarian follicles, the functional unit of the ovary.

Note that this process, important to all animal life cycles, occurs completely without the aid of oo spindle-coordinating centrosomes.

Oogenesis consists of several sub-processes: oocytogenesis, ootidogenesis, and finally maturation to form an ovum. Folliculogenesis is a separate sub-process that occurs during ootidogenesis.

Cell type ploidy Process Process completion
Oogonium diploid Oocytogenesis (mitosis) third trimester (forming oocytes)
primary Oocyte diploid Ootidogenesis (meiosis 1) (Folliculogenesis) Dictyate in prophase I for up to 50 years
secondary Oocyte haploid Ootidogenesis (meiosis 2) Halted in metaphase II until fertilization
Ovum haploid

Oogonium --(Oocytogenesis)--> Primary Oocyte --(Meiosis I)-->First Polar Body (Discarded afterward) + Secondary oocyte --(Meiosis II)--> Secondary Polar Body (Discarded afterward) + Ovum

The Creation of Oogonia

The creation of oogonia traditionally doesn't belong to oogenesis but, instead, to the common process of gametogenesis, which occurs together with the process of spermatogenesis.

Human Oogenesis

At the start of the menstrual cycle, some 12-20 primary follicles begin to develop under the influence of elevated FSH to form secondary follicles. The primary follicles have formed from primordial follicles, which developed in the ovary at around 10–30 weeks after conception. By around day 9 of the cycle, only one healthy secondary follicle remains, with the rest having undergone cellular atresia. The remaining follicle is called the dominant follicle and is responsible for producing large amounts of oestradiol during the late follicular phase. Oestradiol production depends upon co-operation between the theca and granulosa cells. On day 14 of the cycle, an LH surge occurs, which itself is triggered by the positive feedback of oestradiol. This causes the secondary follicle to develop into a tertiary follicle, which then ovulates some 24–36 hours later. An important event in the development of the tertiary follicle occurs when the primary oocyte completes the first meiotic division, resulting in the formation of a polar body and a secondary oocyte. The empty follicle then forms a corpus luteum.[citation needed]


Oogenesis starts with the process of developing oogonia, which occurs via the transformation of primordial follicles into primary oocytes, a process called oocytogenesis.[2] Oocytogenesis is complete either before or shortly after birth.

Number of primary oocytes

It is commonly believed that, when oocytogenesis is complete, no additional primary oocytes are created, in contrast to the male process of spermatogenesis, where gametocytes are continuously created. In other words, oocytes reach their maximum development at ~20[3] weeks of gestational age, when approximately seven million primary oocytes have been created; however, at birth, this number has already been reduced to approximately 1-2 million.

Recently, however, two publications have challenged the belief that a finite number of oocytes are set around the time of birth.[4][5] The renewal of ovarian follicles from germline stem cells (originating from bone marrow and peripheral blood) has been reported in the postnatal mouse ovary.

Due to the revolutionary nature of these claims, further experiments are required to determine the true dynamics of small follicle formation.


The succeeding phase of ootidogenesis occurs when the primary oocyte develops into an ootid. This is achieved by the process of meiosis. In fact, a primary oocyte is, by its biological definition, a cell whose primary function is to divide by the process of meiosis.[6]

However, although this process begins at prenatal age, it stops at prophase I. In late fetal life, all oocytes, still primary oocytes, have halted at this stage of development, called the dictyate. After menarche, these cells then continue to develop, although only a few do so every menstrual cycle.

Meiosis I

Meiosis I of ootidogenesis begins during embryonic development, but halts in the diplotene stage of prophase I until puberty. For those primary oocytes that continue to develop in each menstrual cycle, however, synapsis occurs and tetrads form, enabling Chromosomal crossover to occur. As a result of meiosis I, the primary oocyte has now developed into the secondary oocyte and the first polar body.

Meiosis II

Immediately after meiosis I, the haploid secondary oocyte initiates meiosis II. However, this process is also halted at the metaphase II stage until fertilization, if such should ever occur. When meiosis II has completed, an ootid and another polar body have now been created.


Synchronously with ootidogenesis, the ovarian follicle surrounding the ootid has developed from a primordial follicle to a preovulatory one.

Maturation into ovum

Both polar bodies disintegrate at the end of Meiosis II, leaving only the ootid, which then eventually undergoes maturation into a mature ovum.

The function of forming polar bodies is to discard the extra haploid sets of chromosomes that have resulted as a consequence of meiosis.

Oogenesis in non-mammals

Many protists produce egg cells in structures termed archegonia. Some algae and the oomycetes produce eggs in oogonia. In the brown alga Fucus, all four egg cells survive oogenesis, which is an exception to the rule that generally only one product of female meiosis survives to maturity.

In plants, oogenesis occurs inside the female gametophyte via mitosis. In many plants such as bryophytes, ferns, and gymnosperms, egg cells are formed in archegonia. In flowering plants, the female gametophyte has been reduced to an eight-celled embryo sac within the ovule inside the ovary of the flower. Oogenesis occurs within the embryo sac and leads to the formation of a single egg cell per ovule.

In ascaris, the oocyte does not even begin meiosis until the sperm touches it, in contrast to mammals, where meiosis is completed in the estrus cycle.

See also


  1. ^ Merriam-Webster Online Dictionary Definition: Oogenesis
  2. ^ NCBI - The saga of the germ line
  3. ^ Lobo RA (September 2003). "Early ovarian ageing: a hypothesis. What is early ovarian ageing?". Hum. Reprod. 18 (9): 1762–4. doi:10.1093/humrep/deg377. PMID 12923124. http://humrep.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=12923124. 
  4. ^ Johnson J, Bagley J, Skaznik-Wikiel M, et al. (July 2005). "Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood". Cell 122 (2): 303–15. doi:10.1016/j.cell.2005.06.031. PMID 16051153. 
  5. ^ Johnson J, Canning J, Kaneko T, Pru J, Tilly J (2004). "Germline stem cells and follicular renewal in the postnatal mammalian ovary". Nature 428 (6979): 145–50. doi:10.1038/nature02316. PMID 15014492. 
  6. ^ Biochem

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