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Opiorphin: Wikis


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Symbol  ?
UniProt P85047
Other data
proline rich, lacrimal 1
Symbol PROL1
Entrez 58503
HUGO 17279
OMIM 608936
RefSeq NM_021225
UniProt Q99935
Other data
Locus Chr. 4 q13.3

Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakdown of natural pain-killing opioids in the spine, called enkephalins. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg. [1][2][3][4][5][6][7][8]

Opiorphin pentapetide originates from the N-terminal region of the protein PROL1 (proline rich, lacrimal 1).[1] Opiorphin, inhibits 2 proteases: neutral ecto-endopeptidase (MME) and ecto-aminopeptidase N (ANPEP).[1]

See also


  1. ^ a b c Dickinson DP, Thiesse M (April 1996). "cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein". Curr. Eye Res. 15 (4): 377–86. doi:10.1073/pnas.0605865103. PMID 8670737.  
  2. ^ Andy Coghlan (November 13, 2006). "Natural-born painkiller found in human saliva". New Scientist.  
  3. ^ "Natural chemical 'beats morphine'". BBC News. November 14, 2006.  
  4. ^ Mary Beckman (November 13, 2006). "Prolonging Painkillers". ScienceNOW.  
  5. ^ Stanovic S, Boranic M, Petrovecki M, Batinic D, Skodlar J, Nemet D, Labar B. Haematologia. 2000; 30(1):1-10.
  6. ^ Thanawala V, Kadam VJ, Ghosh R (October 2008). "Enkephalinase inhibitors: potential agents for the management of pain". Current Drug Targets 9 (10): 887–94. PMID 18855623.  
  7. ^ Davies KP (March 2009). "The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology". The Journal of Sexual Medicine 6 Suppl 3: 286–91. doi:10.1111/j.1743-6109.2008.01186.x. PMID 19267851.  
  8. ^ Tian XZ, Chen J, Xiong W, He T, Chen Q (July 2009). "Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice". Peptides 30 (7): 1348–54. doi:10.1016/j.peptides.2009.04.002. PMID 19442408.  


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