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Organ of Zuckerkandl: Wikis

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Organ of Zuckerkandl
Gray531.png
The abdominal aorta and its branches. (Organ of Zuckerkand is not shown, but it usually appears alongside the abdominal aorta.)

The Organ of Zuckerkandl is a chromaffin body derived from neural crest located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery. It can be the source of pheochromocytoma.[1]

The term "paraaortic bodies" is also sometimes used to describe it, as it usually arises near the abdominal aorta, but this term can be the source of confusion, because the term "corpora paraaortica" is also used to describe the aortic body, which arises near the thoracic aorta.

Contents

Function

Its physiological role is thought to be of greatest importance during the early gestational period as a homeostatic regulator of blood pressure, secreting catecholamines into the fetal circulation.

The organ itself regresses in the late third trimester and following birth to form the aorticosympathetic group of the adult paraganglia.

Pathology

It can be the source of paraganglioma.[2]

The Organ of Zuckerkandl is of pathological significance in the adult as the most common extra-adrenal site of pheochromocytoma. Extra-adrenal tumors account for around 10% of all cases of pheochromocytoma.[3] Resection has been described.[4]

In addition to its endocrine effects, it can also cause obstructive pathology.[5]

Eponym

This diffuse group of neuroendocrine sympathetic fibres was first described by Emil Zuckerkandl, a professor of anatomy at the University of Vienna, in 1901.[6]

Nomenclature

Some sources equate the "aortic bodies" and "paraaortic bodies",[7] while other sources explicitly distinguish between the two.[8][9] When a distinction is made, the "aortic bodies" are chemoreceptors which regulate circulation, while the "paraaortic bodies" are the chromaffin cells which manufacture catecholamines.

References

External links

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