The Full Wiki

More info on Oxaflozane

Oxaflozane: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Oxaflozane
Systematic (IUPAC) name
4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
Identifiers
CAS number 26629-86-7
ATC code  ?
PubChem 432824
ChemSpider 382782
Chemical data
Formula C14H18F3NO
Mol. mass 273.29 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Oxaflozane (Conflictan) is an antidepressant of the phenethylamine and morpholine chemical classes that was introduced in France in 1982, but has since been abandoned. [1] [2] It is a prodrug to N-dealkyloxaflozane, which acts as a non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]

References

  1. ^ "Index nominum, international drug ... - Google Books". http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA766&dq=oxaflozane%20conflictan&as_brr=3&pg=PA766#v=onepage&q=oxaflozane%20conflictan&f=false.  
  2. ^ "Pharmaceutical manufacturing ... - Google Books". http://books.google.com/books?id=XCsJgUnclbcC&lpg=PA1122&dq=oxaflozane%20conflictan&as_brr=3&pg=PA1122#v=onepage&q=oxaflozane%20conflictan&f=false.  
  3. ^ Leysen DC (February 1999). "Selective 5-HT2C agonists as potential antidepressants". IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946.  
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). "Oxaflozane overdose in a child". Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141.  

Further reading

  • Rascol A, Maurel H, David J, Layani M (1974). "[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]" (in French). Thérapie 29 (1): 95–9. PMID 4603757.  
  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). "[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]" (in French). Thérapie 29 (1): 81–93. PMID 4849381.  
  • Constantin M, Pognat JF (1979). "Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites". Arzneimittel-Forschung 29 (1): 109–14. PMID 582104.  
  • Bertolino A, palermo M, Porro V (1985). "Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.". Acta Ther (11): 209–218.  
  • Aguglia E (1986). "On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.". Acta Ther (12): 259–267.  

External links








Got something to say? Make a comment.
Your name
Your email address
Message