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Oxaflozane: Wikis


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Systematic (IUPAC) name
CAS number 26629-86-7
ATC code  ?
PubChem 432824
ChemSpider 382782
Chemical data
Formula C14H18F3NO
Mol. mass 273.29 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Oxaflozane (Conflictan) is an antidepressant of the phenethylamine and morpholine chemical classes that was introduced in France in 1982, but has since been abandoned. [1] [2] It is a prodrug to N-dealkyloxaflozane, which acts as a non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]


  1. ^ "Index nominum, international drug ... - Google Books".  
  2. ^ "Pharmaceutical manufacturing ... - Google Books".  
  3. ^ Leysen DC (February 1999). "Selective 5-HT2C agonists as potential antidepressants". IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946.  
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). "Oxaflozane overdose in a child". Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141.  

Further reading

  • Rascol A, Maurel H, David J, Layani M (1974). "[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]" (in French). Thérapie 29 (1): 95–9. PMID 4603757.  
  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). "[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]" (in French). Thérapie 29 (1): 81–93. PMID 4849381.  
  • Constantin M, Pognat JF (1979). "Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites". Arzneimittel-Forschung 29 (1): 109–14. PMID 582104.  
  • Bertolino A, palermo M, Porro V (1985). "Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.". Acta Ther (11): 209–218.  
  • Aguglia E (1986). "On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.". Acta Ther (12): 259–267.  

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