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Oxolinic acid
Systematic (IUPAC) name
5-Ethyl- 8-oxo- 5,8-dihydro [1,3] dioxolo [4,5-g] quinoline- 7-carboxylic acid
Identifiers
CAS number 14698-29-4
ATC code J01MB05
PubChem 4628
Chemical data
Formula C13H11NO5 
Mol. mass 261.23 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status
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Oxolinic acid is a quinolone antibiotic.[1] Dosages 12-20mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA-gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[2]

See also

References

  1. ^ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy 36 (8): 1077–9. PMID 384788. 
  2. ^ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology 8 (4): 255–9. PMID 9928913. http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(97)00083-7. 
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