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Oxprenolol: Wikis


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1 : 1 mixture (racemate)
Systematic (IUPAC) name
CAS number 6452-71-7
ATC code C07AA02
PubChem 4631
Chemical data
Formula C15H23NO3 
Mol. mass 265.348
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 20-70%
Metabolism Hepatic
Half life 1-2hours
Excretion Renal
Lactic (In lactiferous females)
Therapeutic considerations
Pregnancy cat. C(AU)
Legal status Prescription only
Routes oral
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Oxprenolol (Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]

General Practitioners may sometimes be confused by its contrary nature as a Beta Agonist, but Oxprenolol is a potent beta-blocker and should not be administered to asthmatics under any circumstances due to their low Beta levels as a result of depletion due to other Asthma medication, and because it can cause irreversible; often fatal; airway failure and inflammation.[citation needed]


  1. ^ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9–14. PMID 2897304.



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