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Oxyntomodulin is a naturally-occurring 37-amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite. A recent study has found that it can be used as a weight loss treatment.[1][2][3][4]

The mechanism of action of oxyntomodulin is not well understood. It is known to bind both the GLP-1 receptor and the glucagon receptor, but it is not known whether the effects of the hormone are mediated through these receptors or through an unidentified receptor.


  1. ^ Weight loss study Telegraph
  2. ^ Scientists Discover New Weapon Against Obesity-Oxyntomodulin
  3. ^ BBC News story: New way to treat obesity heralded, April 26, 2006
  4. ^ Wynne K, Park AJ, Small CJ, et al. (2006). "Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial". International journal of obesity (2005) 30 (12): 1729–36. doi:10.1038/sj.ijo.0803344. PMID 16619056.  

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