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cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Identifiers
Symbol CDKN2A
Alt. symbols CDKN2, MLM
Entrez 1029
HUGO 1787
OMIM 600160
RefSeq NM_000077
UniProt P42771
Other data
Locus Chr. 9 p21

p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.

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