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Purinergic receptor P2X, ligand-gated ion channel, 2
Identifiers
Symbols P2RX2; MGC129601; P2X2
External IDs OMIM600844 MGI2665170 HomoloGene14251 GeneCards: P2RX2 Gene
RNA expression pattern
PBB GE P2RX2 221372 s at tn.png
PBB GE P2RX2 221356 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22953 231602
Ensembl ENSG00000187848 ENSMUSG00000029503
UniProt Q9UBL9 n/a
RefSeq (mRNA) NM_012226 NM_153400
RefSeq (protein) NP_036358 NP_700449
Location (UCSC) Chr 12:
131.71 - 131.71 Mb
Chr 5:
110.58 - 110.58 Mb
PubMed search [1] [2]

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.[1][2][3]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[3]

Contents

See also

References

  1. ^ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol 56 (6): 1171-81. PMID 10570044.  
  2. ^ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature 371 (6497): 519-23. doi:10.1038/371519a0. PMID 7523952.  
  3. ^ a b "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953.  

Further reading

  • North RA (2002). "Molecular physiology of P2X receptors.". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.  
  • Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.". J. Biol. Chem. 280 (11): 10759–65. doi:10.1074/jbc.M412265200. PMID 15657042.  
  • Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species.". Mol. Pharmacol. 66 (6): 1525–35. doi:10.1124/mol.104.000851. PMID 15331767.  
  • Aschrafi A, Sadtler S, Niculescu C, et al. (2004). "Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes.". J. Mol. Biol. 342 (1): 333–43. doi:10.1016/j.jmb.2004.06.092. PMID 15313628.  
  • Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels.". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Järlebark LE, Housley GD, Raybould NP, et al. (2003). "ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea.". Neuroreport 13 (15): 1979–84. doi:10.1097/00001756-200210280-00030. PMID 12395104.  
  • Khakh BS, Zhou X, Sydes J, et al. (2000). "State-dependent cross-inhibition between transmitter-gated cation channels.". Nature 406 (6794): 405–10. doi:10.1038/35019066. PMID 10935636.  
  • Brändle U, Spielmanns P, Osteroth R, et al. (1997). "Desensitization of the P2X(2) receptor controlled by alternative splicing.". FEBS Lett. 404 (2-3): 294–8. doi:10.1016/S0014-5793(97)00128-2. PMID 9119082.  
  • Lewis C, Neidhart S, Holy C, et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.". Nature 377 (6548): 432–5. doi:10.1038/377432a0. PMID 7566120.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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