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Purinergic receptor P2X-like 1, orphan receptor
Identifiers
Symbols P2RXL1; MGC129625; P2RX6; P2X6; P2XM
External IDs OMIM608077 MGI1337113 HomoloGene3975 GeneCards: P2RXL1 Gene
RNA expression pattern
PBB GE P2RXL1 206880 at tn.png
PBB GE P2RXL1 211147 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9127 18440
Ensembl ENSG00000099957 ENSMUSG00000022758
UniProt O15547 Q3UUD0
RefSeq (mRNA) NM_005446 NM_011028
RefSeq (protein) NP_005437 NP_035158
Location (UCSC) Chr 22:
19.7 - 19.71 Mb
Chr 16:
17.48 - 17.49 Mb
PubMed search [1] [2]

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[1][2][3][4]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[4]

Contents

See also

References

  1. ^ Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res 57 (15): 3281-7. PMID 9242461.  
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.  
  3. ^ Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci 16 (8): 2495-507. PMID 8786426.  
  4. ^ a b "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9127.  

Further reading

  • Khakh BS, Burnstock G, Kennedy C, et al. (2001). "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.". Pharmacol. Rev. 53 (1): 107–18. PMID 11171941.  
  • Soto F, Garcia-Guzman M, Karschin C, Stühmer W (1996). "Cloning and tissue distribution of a novel P2X receptor from rat brain.". Biochem. Biophys. Res. Commun. 223 (2): 456–60. doi:10.1006/bbrc.1996.0915. PMID 8670303.  
  • Glass R, Loesch A, Bodin P, Burnstock G (2002). "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells.". Cell. Mol. Life Sci. 59 (5): 870–81. doi:10.1007/s00018-002-8474-y. PMID 12088286.  
  • Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets.". Proteomics 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Barrera NP, Ormond SJ, Henderson RM, et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.". J. Biol. Chem. 280 (11): 10759–65. doi:10.1074/jbc.M412265200. PMID 15657042.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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