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Purinergic receptor P2X, ligand-gated ion channel, 7
Symbols P2RX7; MGC20089; P2X7
External IDs OMIM602566 MGI1339957 HomoloGene1925 GeneCards: P2RX7 Gene
RNA expression pattern
PBB GE P2RX7 207091 at tn.png
More reference expression data
Species Human Mouse
Entrez 5027 18439
Ensembl ENSG00000089041 ENSMUSG00000029468
UniProt Q99572 Q3UN00
RefSeq (mRNA) NM_002562 NM_001038839
RefSeq (protein) NP_002553 NP_001033928
Location (UCSC) Chr 12:
120.06 - 120.11 Mb
Chr 5:
122.9 - 122.95 Mb
PubMed search [1] [2]

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.[3]

In melanocytic cells P2RX7 gene expression may be regulated by MITF[4].


See also


  1. ^ Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A (Apr 1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA". J Biol Chem 272 (9): 5482-6. PMID 9038151.  
  2. ^ Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE (Feb 1999). "Gene structure and chromosomal localization of the human P2X7 receptor". Receptors Channels 5 (6): 347-54. PMID 9826911.  
  3. ^ "Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7".  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  

Further reading

  • Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA. (2003). "P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 237–42. doi:10.1615/CritRevEukaryotGeneExpr.v13.i24.150. PMID 14696970.  
  • Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003). "Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.". Calcif Tissue Int. 72 (4): 361–9. doi:10.1007/s00223-002-2098-y. PMID 12874700.  
  • Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G, Gallagher JA. (2001). "Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.". Bone 28 (5): 507–12. doi:10.1016/S8756-3282(01)00430-6. PMID 11344050.  
  • Gartland A, Hipskind RA, Gallagher JA, Bowler WB. (2001). "Expression of a P2X7 receptor by a subpopulation of human osteoblasts.". J Bone Miner Res . 16 (5): 846–56. doi:10.1359/jbmr.2001.16.5.846. PMID 11341329.  
  • Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. (2003). "Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 243–53. doi:10.1615/CritRevEukaryotGeneExpr.v13.i24.160. PMID 14696971.  
  • North RA (2002). "Molecular physiology of P2X receptors.". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Gu BJ, Zhang W, Worthington RA, et al. (2001). "A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.". J. Biol. Chem. 276 (14): 11135–42. doi:10.1074/jbc.M010353200. PMID 11150303.  
  • Kim M, Jiang LH, Wilson HL, et al. (2002). "Proteomic and functional evidence for a P2X7 receptor signalling complex.". Embo J. 20 (22): 6347–58. doi:10.1093/emboj/20.22.6347. PMID 11707406.  
  • Worthington RA, Smart ML, Gu BJ, et al. (2002). "Point mutations confer loss of ATP-induced human P2X(7) receptor function.". FEBS Lett. 512 (1-3): 43–6. doi:10.1016/S0014-5793(01)03311-7. PMID 11852049.  
  • Wiley JS, Dao-Ung LP, Gu BJ, et al. (2002). "A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study.". Lancet 359 (9312): 1114–9. doi:10.1016/S0140-6736(02)08156-4. PMID 11943260.  
  • Wilson HL, Wilson SA, Surprenant A, North RA (2002). "Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.". J. Biol. Chem. 277 (37): 34017–23. doi:10.1074/jbc.M205120200. PMID 12107182.  
  • Atkinson L, Milligan CJ, Buckley NJ, Deuchars J (2002). "An ATP-gated ion channel at the cell nucleus.". Nature 420 (6911): 42. doi:10.1038/420042a. PMID 12422208.  
  • Budagian V, Bulanova E, Brovko L, et al. (2003). "Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B.". J. Biol. Chem. 278 (3): 1549–60. doi:10.1074/jbc.M206383200. PMID 12424250.  
  • Sluyter R, Wiley JS (2003). "Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.". Int. Immunol. 14 (12): 1415–21. doi:10.1093/intimm/dxf111. PMID 12456589.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Wiley JS, Dao-Ung LP, Li C, et al. (2003). "An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.". J. Biol. Chem. 278 (19): 17108–13. doi:10.1074/jbc.M212759200. PMID 12586825.  
  • Barden JA, Sluyter R, Gu BJ, Wiley JS (2003). "Specific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytes.". FEBS Lett. 538 (1-3): 159–62. doi:10.1016/S0014-5793(03)00172-8. PMID 12633871.  
  • Verhoef PA, Estacion M, Schilling W, Dubyak GR (2003). "P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.". J. Immunol. 170 (11): 5728–38. PMID 12759456.  
  • Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.  
  • Denlinger LC, Sommer JA, Parker K, et al. (2003). "Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function.". J. Immunol. 171 (3): 1304–11. PMID 12874219.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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