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Purinergic receptor P2Y, G-protein coupled, 11
Symbols P2RY11; P2Y11
External IDs OMIM602697 IUPHAR: P2Y11 GeneCards: P2RY11 Gene
RNA expression pattern
PBB GE P2RY11 214546 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5032 n/a
Ensembl ENSG00000176130 n/a
UniProt Q96G91 n/a
RefSeq (mRNA) NM_002566 n/a
RefSeq (protein) NP_002557 n/a
Location (UCSC) Chr 19:
10.08 - 10.09 Mb
PubMed search [1] n/a

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[1][2]

The product of this gene, P2Y11, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[2]


See also


  1. ^ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem 272 (51): 31969-73. PMID 9405388.  
  2. ^ a b "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11".  

External links

Further reading

  • van der Weyden L, Conigrave AD, Morris MB (2000). "Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor.". Immunol. Cell Biol. 78 (4): 369–74. doi:10.1046/j.1440-1711.2000.00918.x. PMID 10947861.  
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.  
  • Communi D, Suarez-Huerta N, Dussossoy D, et al. (2001). "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.". J. Biol. Chem. 276 (19): 16561–6. doi:10.1074/jbc.M009609200. PMID 11278528.  
  • Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.  
  • Duhant X, Schandené L, Bruyns C, et al. (2002). "Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes.". J. Immunol. 169 (1): 15–21. PMID 12077223.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Moreschi I, Bruzzone S, Nicholas RA, et al. (2006). "Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.". J. Biol. Chem. 281 (42): 31419–29. doi:10.1074/jbc.M606625200. PMID 16926152.  
  • Zylberg J, Ecke D, Fischer B, Reiser G (2007). "Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis.". Biochem. J. 405 (2): 277–86. doi:10.1042/BJ20061728. PMID 17338680.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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