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Purinergic receptor P2Y, G-protein coupled, 8
Symbols P2RY8; MGC50878; P2Y8
External IDs OMIM300525 HomoloGene65345 IUPHAR: P2RY8 GeneCards: P2RY8 Gene
RNA expression pattern
PBB GE P2RY8 gnf1h10171 at tn.png
PBB GE P2RY8 gnf1h10172 s at tn.png
More reference expression data
Species Human Mouse
Entrez 286530 n/a
Ensembl ENSG00000182162 n/a
UniProt Q86VZ1 n/a
RefSeq (mRNA) NM_178129 n/a
RefSeq (protein) NP_835230 n/a
Location (UCSC) Chr X:
1.54 - 1.62 Mb
PubMed search [1] n/a

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[1][2]

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[2]

See also


  1. ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim Biophys Acta 1492 (1): 127-38. PMID 11004484.  
  2. ^ a b "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8".  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Cantagrel V, Lossi AM, Boulanger S, et al. (2005). "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.". J. Med. Genet. 41 (10): 736–42. doi:10.1136/jmg.2004.021626. PMID 15466006.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Fujiwara S, Yamashita Y, Choi YL, et al. (2007). "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.". Leuk. Lymphoma 48 (5): 978–86. doi:10.1080/10428190701225882. PMID 17487742.  
  • Storlazzi CT, Albano F, Lo Cunsolo C, et al. (2007). "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.". Leukemia 21 (10): 2221–5. doi:10.1038/sj.leu.2404784. PMID 17554380.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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