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Proliferation-associated 2G4, 38kDa
Identifiers
Symbols PA2G4; EBP1; HG4-1; p38-2G4
External IDs OMIM602145 MGI894684 HomoloGene4513 GeneCards: PA2G4 Gene
RNA expression pattern
PBB GE PA2G4 208676 s at tn.png
PBB GE PA2G4 214794 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5036 18813
Ensembl ENSG00000170515 n/a
UniProt Q9UQ80 n/a
RefSeq (mRNA) NM_006191 NM_011119
RefSeq (protein) NP_006182 NP_035249
Location (UCSC) Chr 12:
54.78 - 54.79 Mb
n/a
PubMed search [1] [2]

Proliferation-associated protein 2G4 is a protein that in humans is encoded by the PA2G4 gene.[1]

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.[2]

Interactions

PA2G4 has been shown to interact with ERBB3,[3][4] Retinoblastoma protein[5] and Androgen receptor.[6]

References

  1. ^ Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS (Nov 1997). "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4". Cytogenet Cell Genet 78 (1): 31–5. PMID 9345902.  
  2. ^ "Entrez Gene: PA2G4 proliferation-associated 2G4, 38kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5036.  
  3. ^ Lessor, T J; Hamburger A W (Apr. 2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C". Mol. Cell. Endocrinol. (Ireland) 175 (1-2): 185–91. ISSN 0303-7207. PMID 11325528.  
  4. ^ Yoo, J Y; Wang X W, Rishi A K, Lessor T, Xia X M, Gustafson T A, Hamburger A W (Feb. 2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin". Br. J. Cancer (SCOTLAND) 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. ISSN 0007-0920. PMID 10682683.  
  5. ^ Xia, X; Cheng A, Lessor T, Zhang Y, Hamburger A W (May. 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation". J. Cell. Physiol. (United States) 187 (2): 209–17. doi:10.1002/jcp.1075. ISSN 0021-9541. PMID 11268000.  
  6. ^ Zhang, Yuexing; Fondell Joseph D, Wang Qianben, Xia Xianmin, Cheng Aiwu, Lu Michael L, Hamburger Anne W (Aug. 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene (England) 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. ISSN 0950-9232. PMID 12165860.  

Further reading

  • Radomski N, Jost E (1995). "Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle.". Exp. Cell Res. 220 (2): 434–45. doi:10.1006/excr.1995.1335. PMID 7556453.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Froesch BA, Takayama S, Reed JC (1998). "BAG-1L protein enhances androgen receptor function.". J. Biol. Chem. 273 (19): 11660–6. doi:10.1074/jbc.273.19.11660. PMID 9565586.  
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.  
  • Yoo JY, Wang XW, Rishi AK, et al. (2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.". Br. J. Cancer 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. PMID 10682683.  
  • Lessor TJ, Yoo JY, Xia X, et al. (2000). "Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines.". J. Cell. Physiol. 183 (3): 321–9. doi:10.1002/(SICI)1097-4652(200006)183:3<321::AID-JCP4>3.0.CO;2-O. PMID 10797306.  
  • Xia X, Cheng A, Lessor T, et al. (2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation.". J. Cell. Physiol. 187 (2): 209–17. doi:10.1002/jcp.1075. PMID 11268000.  
  • Lessor TJ, Hamburger AW (2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.". Mol. Cell. Endocrinol. 175 (1-2): 185–91. doi:10.1016/S0303-7207(01)00387-2. PMID 11325528.  
  • Xia X, Lessor TJ, Zhang Y, et al. (2001). "Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein.". Biochem. Biophys. Res. Commun. 289 (1): 240–4. doi:10.1006/bbrc.2001.5942. PMID 11708806.  
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.  
  • Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1.". Oncogene 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.  
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang Y, Woodford N, Xia X, Hamburger AW (2003). "Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.". Nucleic Acids Res. 31 (8): 2168–77. doi:10.1093/nar/gkg318. PMID 12682367.  
  • Squatrito M, Mancino M, Donzelli M, et al. (2004). "EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.". Oncogene 23 (25): 4454–65. doi:10.1038/sj.onc.1207579. PMID 15064750.  
  • Zhang Y, Hamburger AW (2004). "Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription.". J. Biol. Chem. 279 (25): 26126–33. doi:10.1074/jbc.M314305200. PMID 15073182.  
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zhang Y, Hamburger AW (2005). "Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling.". Br. J. Cancer 92 (1): 140–6. doi:10.1038/sj.bjc.6602257. PMID 15583694.  
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