The Full Wiki

More info on PAX7

PAX7: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Paired box gene 7
Identifiers
Symbols PAX7; HUP1; PAX7B
External IDs OMIM167410 MGI97491 HomoloGene55665 GeneCards: PAX7 Gene
RNA expression pattern
PBB GE PAX7 208060 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5081 18509
Ensembl ENSG00000009709 ENSMUSG00000028736
UniProt P23759 Q7TPG3
RefSeq (mRNA) NM_002584 NM_011039
RefSeq (protein) NP_002575 NP_035169
Location (UCSC) Chr 1:
18.83 - 18.94 Mb
Chr 4:
139.01 - 139.11 Mb
PubMed search [1] [2]

Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.[1][2][3]

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box gene 7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.[3]

Contents

See also

References

  1. ^ Stapleton P, Weith A, Urbanek P, Kozmik Z, Busslinger M (Jan 1995). "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Nat Genet 3 (4): 292-8. doi:10.1038/ng0493-292. PMID 7981748.  
  2. ^ Pilz AJ, Povey S, Gruss P, Abbott CM (Mar 1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mamm Genome 4 (2): 78-82. PMID 8431641.  
  3. ^ a b "Entrez Gene: PAX7 paired box gene 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5081.  

Further reading

  • Blake J, Ziman MR (2003). "Aberrant PAX3 and PAX7 expression. A link to the metastatic potential of embryonal rhabdomyosarcoma and cutaneous malignant melanoma?". Histol. Histopathol. 18 (2): 529–39. PMID 12647804.  
  • Burri M, Tromvoukis Y, Bopp D, et al. (1989). "Conservation of the paired domain in metazoans and its structure in three isolated human genes.". Embo J. 8 (4): 1183–90. PMID 2501086.  
  • Schäfer BW, Czerny T, Bernasconi M, et al. (1995). "Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes.". Nucleic Acids Res. 22 (22): 4574–82. doi:10.1093/nar/22.22.4574. PMID 7527137.  
  • Shapiro DN, Sublett JE, Li B, et al. (1993). "The gene for PAX7, a member of the paired-box-containing genes, is localized on human chromosome arm 1p36.". Genomics 17 (3): 767–9. doi:10.1006/geno.1993.1404. PMID 7902328.  
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.  
  • Schäfer BW, Mattei MG (1993). "The human paired domain gene PAX7 (Hup1) maps to chromosome 1p35-1p36.2.". Genomics 17 (1): 249–51. doi:10.1006/geno.1993.1315. PMID 8104868.  
  • Barr FG, Nauta LE, Davis RJ, et al. (1996). "In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma.". Hum. Mol. Genet. 5 (1): 15–21. doi:10.1093/hmg/5.1.15. PMID 8789435.  
  • Vorobyov E, Mertsalov I, Dockhorn-Dworniczak B, et al. (1997). "The genomic organization and the full coding region of the human PAX7 gene.". Genomics 45 (1): 168–74. doi:10.1006/geno.1997.4915. PMID 9339373.  
  • Magnaghi P, Roberts C, Lorain S, et al. (1998). "HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.". Nat. Genet. 20 (1): 74–7. doi:10.1038/1739. PMID 9731536.  
  • Margue CM, Bernasconi M, Barr FG, Schäfer BW (2000). "Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.". Oncogene 19 (25): 2921–9. doi:10.1038/sj.onc.1203607. PMID 10871843.  
  • Kondrashov AV, Pospelov VA (2002). "[In vitro modelling of the interactions between the promoter and enhancer complexes]". Tsitologiia 43 (8): 764–71. PMID 11601392.  
  • Sorensen PH, Lynch JC, Qualman SJ, et al. (2002). "PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.". J. Clin. Oncol. 20 (11): 2672–9. doi:10.1200/JCO.2002.03.137. PMID 12039929.  
  • Syagailo YV, Okladnova O, Reimer E, et al. (2003). "Structural and functional characterization of the human PAX7 5'-flanking regulatory region.". Gene 294 (1-2): 259–68. doi:10.1016/S0378-1119(02)00798-9. PMID 12234688.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tiffin N, Williams RD, Shipley J, Pritchard-Jones K (2003). "PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells.". Br. J. Cancer 89 (2): 327–32. doi:10.1038/sj.bjc.6601040. PMID 12865925.  
  • Tomescu O, Xia SJ, Strezlecki D, et al. (2004). "Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.". Lab. Invest. 84 (8): 1060–70. doi:10.1038/labinvest.3700125. PMID 15184910.  
  • Vorobyov E, Horst J (2005). "Expression of two protein isoforms of PAX7 is controlled by competing cleavage-polyadenylation and splicing.". Gene 342 (1): 107–12. doi:10.1016/j.gene.2004.07.030. PMID 15527970.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message