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Pre-B-cell leukemia homeobox 2

Cartoon diagram of a HOXB1PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
1b72, 1b8i, 1du6, 1lfu, 1puf
Symbols PBX2; G17; HOX12; PBX2MHC
External IDs OMIM176311 MGI1341793 HomoloGene48115 GeneCards: PBX2 Gene
RNA expression pattern
PBB GE PBX2 202876 s at tn.png
PBB GE PBX2 202875 s at tn.png
PBB GE PBX2 211096 at tn.png
More reference expression data
Species Human Mouse
Entrez 5089 18515
Ensembl ENSG00000204304 ENSMUSG00000034673
UniProt P40425 Q3TMM2
RefSeq (mRNA) NM_002586 XM_994405
RefSeq (protein) NP_002577 XP_999499
Location (UCSC) Chr 6:
32.26 - 32.27 Mb
Chr 17:
34.2 - 34.21 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[1][2]

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[2]



PBX2 has been shown to interact with HOXA9.[3]


  1. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Feb 1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics 23 (2): 408–19. PMID 7835890.  
  2. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".  
  3. ^ Shen, W F; Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C (Apr. 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMID 10082572.  

Further reading

  • Monica K, Galili N, Nourse J, et al. (1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.". Mol. Cell. Biol. 11 (12): 6149–57. PMID 1682799.  
  • Aguado B, Campbell RD (1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein.". Genomics 25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.  
  • Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.". Mol. Cell. Biol. 14 (6): 3938–48. PMID 7910944.  
  • Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci.". Genomics 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.  
  • Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins.". EMBO J. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMID 9482739.  
  • Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.". Mol. Cell. Biol. 19 (4): 3051–61. PMID 10082572.  
  • Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.  
  • Brake RL, Kees UR, Watt PM (2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11.". Biochem. Biophys. Res. Commun. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Okada Y, Nagai R, Sato T, et al. (2004). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.". Blood 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.  
  • Longobardi E, Blasi F (2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation.". J. Biol. Chem. 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.  
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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