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Pre-B-cell leukemia homeobox 3

Cartoon diagram of a HOXB1PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
1b72, 1b8i, 1du6, 1lfu, 1puf
Symbols PBX3;
External IDs OMIM176312 MGI97496 HomoloGene21243 GeneCards: PBX3 Gene
RNA expression pattern
PBB GE PBX3 204082 at tn.png
More reference expression data
Species Human Mouse
Entrez 5090 18516
Ensembl ENSG00000167081 ENSMUSG00000038718
UniProt P40426 O35317
RefSeq (mRNA) NM_006195 XM_992943
RefSeq (protein) NP_006186 XP_998037
Location (UCSC) Chr 9:
127.55 - 127.77 Mb
Chr 2:
33.99 - 34.19 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.[1][2]


Further reading

  • Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.". Mol. Cell. Biol. 14 (6): 3938–48. PMID 7910944.  
  • Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.". Mol. Cell. Biol. 19 (4): 3051–61. PMID 10082572.  
  • Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.  
  • Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.". Oncogene 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Rhee JW, Arata A, Selleri L, et al. (2004). "Pbx3 deficiency results in central hypoventilation.". Am. J. Pathol. 165 (4): 1343–50. PMID 15466398.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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