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Pre-B-cell leukemia homeobox 3

Cartoon diagram of a HOXB1PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
1b72, 1b8i, 1du6, 1lfu, 1puf
Identifiers
Symbols PBX3;
External IDs OMIM176312 MGI97496 HomoloGene21243 GeneCards: PBX3 Gene
RNA expression pattern
PBB GE PBX3 204082 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5090 18516
Ensembl ENSG00000167081 ENSMUSG00000038718
UniProt P40426 O35317
RefSeq (mRNA) NM_006195 XM_992943
RefSeq (protein) NP_006186 XP_998037
Location (UCSC) Chr 9:
127.55 - 127.77 Mb
Chr 2:
33.99 - 34.19 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.[1][2]

References

Further reading

  • Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.". Mol. Cell. Biol. 14 (6): 3938–48. PMID 7910944.  
  • Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.". Mol. Cell. Biol. 19 (4): 3051–61. PMID 10082572.  
  • Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.  
  • Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.". Oncogene 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  
  • Rhee JW, Arata A, Selleri L, et al. (2004). "Pbx3 deficiency results in central hypoventilation.". Am. J. Pathol. 165 (4): 1343–50. PMID 15466398.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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