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PDE4A: Wikis


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Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)

PDB rendering based on 1loi.
Available structures
Symbols PDE4A; DPDE2; PDE4
External IDs OMIM600126 MGI99558 HomoloGene4520 GeneCards: PDE4A Gene
RNA expression pattern
PBB GE PDE4A 204735 at tn.png
PBB GE PDE4A 211447 s at tn.png
PBB GE PDE4A 211591 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5141 18577
Ensembl ENSG00000065989 ENSMUSG00000032177
UniProt P27815 O70285
RefSeq (mRNA) NM_006202 XM_977087
RefSeq (protein) NP_006193 XP_982181
Location (UCSC) Chr 19:
10.39 - 10.44 Mb
Chr 9:
20.92 - 20.96 Mb
PubMed search [1] [2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.[1][2]


PDE4A has been shown to interact with AKAP6[3] and PRKAR2A.[3]


  1. ^ Milatovich A, Bolger G, Michaeli T, Francke U (Jul 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat Cell Mol Genet 20 (2): 75–86. PMID 8009369.  
  2. ^ "Entrez Gene: PDE4A phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)".  
  3. ^ a b Dodge, K L; Khouangsathiene S, Kapiloff M S, Mouton R, Hill E V, Houslay M D, Langeberg L K, Scott J D (Apr. 2001). "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". EMBO J. (England) 20 (8): 1921–30. doi:10.1093/emboj/20.8.1921. ISSN 0261-4189. PMID 11296225.  

Further reading

  • Houslay MD, Schafer P, Zhang KY (2006). "Keynote review: phosphodiesterase-4 as a therapeutic target.". Drug Discov. Today 10 (22): 1503–19. doi:10.1016/S1359-6446(05)03622-6. PMID 16257373.  
  • Zhang KY, Ibrahim PN, Gillette S, Bollag G (2006). "Phosphodiesterase-4 as a potential drug target.". Expert Opin. Ther. Targets 9 (6): 1283–305. doi:10.1517/14728222.9.6.1283. PMID 16300476.  
  • Livi GP, Kmetz P, McHale MM, et al. (1990). "Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.". Mol. Cell. Biol. 10 (6): 2678–86. PMID 2160582.  
  • Horton YM, Sullivan M, Houslay MD (1995). "Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]". Biochem. J. 308 ( Pt 2): 683–91. PMID 7772058.  
  • Sullivan M, Egerton M, Shakur Y, et al. (1995). "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1).". Cell. Signal. 6 (7): 793–812. doi:10.1016/0898-6568(94)00039-5. PMID 7888306.  
  • Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.". Mol. Cell. Biol. 13 (10): 6558–71. PMID 8413254.  
  • Huston E, Pooley L, Julien P, et al. (1997). "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.". J. Biol. Chem. 271 (49): 31334–44. doi:10.1074/jbc.271.49.31334. PMID 8940140.  
  • Sullivan M, Rena G, Begg F, et al. (1998). "Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2.". Biochem. J. 333 ( Pt 3): 693–703. PMID 9677330.  
  • McPhee I, Yarwood SJ, Scotland G, et al. (1999). "Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.". J. Biol. Chem. 274 (17): 11796–810. doi:10.1074/jbc.274.17.11796. PMID 10206997.  
  • Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.  
  • Secchiero P, Zella D, Curreli S, et al. (2001). "Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14620–5. doi:10.1073/pnas.011512398. PMID 11114167.  
  • Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.  
  • Rena G, Begg F, Ross A, et al. (2001). "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.". Mol. Pharmacol. 59 (5): 996–1011. PMID 11306681.  
  • Lario PI, Bobechko B, Bateman K, et al. (2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells.". Arch. Biochem. Biophys. 394 (1): 54–60. doi:10.1006/abbi.2001.2513. PMID 11566027.  
  • Moon E, Lee R, Near R, et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.". Clin. Cancer Res. 8 (2): 589–95. PMID 11839681.  
  • Laliberté F, Liu S, Gorseth E, et al. (2002). "In vitro PKA phosphorylation-mediated human PDE4A4 activation.". FEBS Lett. 512 (1-3): 205–8. doi:10.1016/S0014-5793(02)02259-7. PMID 11852080.  
  • Baillie GS, Huston E, Scotland G, et al. (2002). "TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.". J. Biol. Chem. 277 (31): 28298–309. doi:10.1074/jbc.M108353200. PMID 11994273.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Pryzwansky KB, Madden VJ (2004). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils.". Cell Tissue Res. 312 (3): 301–11. doi:10.1007/s00441-003-0728-y. PMID 12764607.  


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