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Platelet-derived growth factor receptor, beta polypeptide
Symbols PDGFRB; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1
External IDs OMIM173410 MGI97531 HomoloGene1960 GeneCards: PDGFRB Gene
RNA expression pattern
PBB GE PDGFRB 202273 at tn.png
More reference expression data
Species Human Mouse
Entrez 5159 18596
Ensembl ENSG00000113721 ENSMUSG00000024620
UniProt P09619 Q003I5
RefSeq (mRNA) NM_002609 NM_008809
RefSeq (protein) NP_002600 NP_032835
Location (UCSC) Chr 5:
149.47 - 149.52 Mb
Chr 18:
61.17 - 61.21 Mb
PubMed search [1] [2]

Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.[1]



PDGFRB has been shown to interact with PTPN11,[2][3] NCK1,[4][5] Grb2,[6][7][5] Caveolin 1,[8] PDGFRA,[9][10] Sodium-hydrogen antiporter 3 regulator 1,[11] RAS p21 protein activator 1,[12][13] CRK,[14] SHC1[15] and NCK2.[16][17][5]

See also


  1. ^ "Entrez Gene: PDGFRB platelet-derived growth factor receptor, beta polypeptide".  
  2. ^ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (Jan. 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. (United States) 152 (2): 325–34. ISSN 0021-9525. PMID 11266449.  
  3. ^ Lechleider, R J; Sugimoto S, Bennett A M, Kashishian A S, Cooper J A, Shoelson S E, Walsh C T, Neel B G (Oct. 1993). "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor". J. Biol. Chem. (UNITED STATES) 268 (29): 21478–81. ISSN 0021-9258. PMID 7691811.  
  4. ^ Li, W; Hu P, Skolnik E Y, Ullrich A, Schlessinger J (Dec. 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors". Mol. Cell. Biol. (UNITED STATES) 12 (12): 5824–33. ISSN 0270-7306. PMID 1333047.  
  5. ^ a b c Braverman, L E; Quilliam L A (Feb. 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–9. ISSN 0021-9258. PMID 10026169.  
  6. ^ Arvidsson, A K; Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin C H, Claesson-Welsh L (Oct. 1994). "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". Mol. Cell. Biol. (UNITED STATES) 14 (10): 6715–26. ISSN 0270-7306. PMID 7935391.  
  7. ^ Tang, J; Feng G S, Li W (Oct. 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene (ENGLAND) 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. ISSN 0950-9232. PMID 9362449.  
  8. ^ Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (Mar. 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366.  
  9. ^ Rupp, E; Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin C H (Oct. 1994). "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". Eur. J. Biochem. (GERMANY) 225 (1): 29–41. ISSN 0014-2956. PMID 7523122.  
  10. ^ Seifert, R A; Hart C E, Phillips P E, Forstrom J W, Ross R, Murray M J, Bowen-Pope D F (May. 1989). "Two different subunits associate to create isoform-specific platelet-derived growth factor receptors". J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288.  
  11. ^ Maudsley, S; Zamah A M, Rahman N, Blitzer J T, Luttrell L M, Lefkowitz R J, Hall R A (Nov. 2000). "Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. ISSN 0270-7306. PMID 11046132.  
  12. ^ Farooqui, T; Kelley T, Coggeshall K M, Rampersaud A A, Yates A J. "GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells". Anticancer Res. (GREECE) 19 (6B): 5007–13. ISSN 0250-7005. PMID 10697503.  
  13. ^ Ekman, Simon; Kallin Anders, Engström Ulla, Heldin Carl-Henrik, Rönnstrand Lars (Mar. 2002). "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor". Oncogene (England) 21 (12): 1870–5. doi:10.1038/sj.onc.1205210. ISSN 0950-9232. PMID 11896619.  
  14. ^ Matsumoto, T; Yokote K, Take A, Takemoto M, Asaumi S, Hashimoto Y, Matsuda M, Saito Y, Mori S (Apr. 2000). "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. doi:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900.  
  15. ^ Yokote, K; Mori S, Hansen K, McGlade J, Pawson T, Heldin C H, Claesson-Welsh L (May. 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem. (UNITED STATES) 269 (21): 15337–43. ISSN 0021-9258. PMID 8195171.  
  16. ^ Chen, M; She H, Davis E M, Spicer C M, Kim L, Ren R, Le Beau M M, Li W (Sep. 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. (UNITED STATES) 273 (39): 25171–8. ISSN 0021-9258. PMID 9737977.  
  17. ^ Chen, M; She H, Kim A, Woodley D T, Li W (Nov. 2000). "Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb". Mol. Cell. Biol. (UNITED STATES) 20 (21): 7867–80. ISSN 0270-7306. PMID 11027258.  

Further reading

  • Hart CE, Bowen-Pope DF (1990). "Platelet-derived growth factor receptor: current views of the two-subunit model.". J. Invest. Dermatol. 94 (6 Suppl): 53S–57S. doi:10.1111/1523-1747.ep12875065. PMID 2161888.  
  • Steer EJ, Cross NC (2002). "Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta.". Acta Haematol. 107 (2): 113–22. doi:10.1159/000046641. PMID 11919393.  

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