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PEAQX
Systematic (IUPAC) name
({[(1S)-1-(4-bromophenyl)ethyl]amino}-(2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl)phosphonic acid
Identifiers
CAS number  ?
ATC code  ?
PubChem  ?
Chemical data
Formula C 17H17BrN3O5P 
Mol. mass 454.211 g/mol
SMILES eMolecules & PubChem
Synonyms PEAQX
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

PEAQX is a competitive antagonist at the NMDA receptor. It is subtype-selective, with a 100x selectivity for NMDA receptors composed of 1A/2A subunits vs the 1A/2B subunit composition. It is also a potent anticonvulsant in animal tests.[1]

References

  1. ^ Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorganic and Medicinal Chemistry Letters. 2002 Apr 8;12(7):1099-102. PMID 11909726
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