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PEPAP
Systematic (IUPAC) name
4-phenyl-1-(2-phenylethyl)piperidin-4-yl acetate
Identifiers
CAS number 64-52-8
ATC code  ?
PubChem 60977
Chemical data
Formula C 21H25NO2  
Mol. mass 323.43 g/mol
Synonyms PEPAP
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Class A (UK) Schedule I (US)
Routes  ?

PEPAP is an opioid analgesic that is an analogue of pethidine (meperidine).

It is related to the drug MPPP, with a phenethyl group in place of the 1-methyl substitution and an acetate ester rather than propionate.

PEPAP presumably has similar effects to other opioids, producing analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.

PEPAP could be particularly dangerous as it has been found to be a potent CYP2D6 inhibitor, which makes it likely to cause adverse interactions with some other drugs.[1] (Both cocaine and methadone are also CYP2D6 inhibitors and could, in theory, potentiate the effect.)

It is however not known whether the byproducts formed during the synthesis of PEPAP are neurotoxic in the same way as the MPPP byproduct MPTP.

References

  1. ^ Pritzker D, Kanungo A, Kilicarslan T, Tyndale RF, Sellers EM. Designer drugs that are potent inhibitors of CYP2D6. Journal of Clinical Psychopharmacology. 2002 Jun;22(3):330-2.
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