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For the process algebra, see PEPA
PEPA (drug)
Systematic (IUPAC) name
CAS number 141286-78-4
ATC code  ?
PubChem 6603828
Chemical data
Formula C16H16F2N2O4S2 
Mol. mass 402.436 g/mol
SMILES eMolecules & PubChem
Synonyms PEPA
Therapeutic considerations
Pregnancy cat.  ?
Legal status Investigational New Medicine

PEPA is an ampakine drug which acts as an allosteric potentiator of AMPA receptor desensitisation,[1][2] which is up to 100x more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]


  1. ^ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. British Journal of Pharmacology. 1998 Apr;123(7):1294-303. PMID 9579722
  2. ^ Sekiguchi M, Nishikawa K, Aoki S, Wada K. A desensitization-selective potentiator of AMPA-type glutamate receptors. British Journal of Pharmacology. 2002 Aug;136(7):1033-41. PMID 12145103
  3. ^ Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K. A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide. Journal of Neuroscience. 1997 Aug 1;17(15):5760-71. PMID 9221774
  4. ^ Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, Kamichi S, Kimura I, Wada K. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport. 2001 Sep 17;12(13):2947-50. PMID 11588608

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