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PHA-543,613: Wikis

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PHA-543,613
Systematic (IUPAC) name
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide
Identifiers
CAS number 478149-53-0
ATC code  ?
PubChem 11493927
Chemical data
Formula C15H17N3O2 
Mol. mass 271.314
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

PHA-543,613 is a drug which acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.[1]

References

  1. ^ Wishka, D.; Walker, D.; Yates, K.; Reitz, S.; Jia, S.; Myers, J.; Olson, K.; Jacobsen, E. et al. (2006). "Discovery of N-(3R)-1-azabicyclo2.2.2oct-3-ylfuro2,3-cpyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship". Journal of medicinal chemistry 49 (14): 4425–4436. doi:10.1021/jm0602413. PMID 16821801.  edit
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