The Full Wiki

More info on PHA-543,613

PHA-543,613: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 478149-53-0
ATC code  ?
PubChem 11493927
Chemical data
Formula C15H17N3O2 
Mol. mass 271.314
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

PHA-543,613 is a drug which acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.[1]


  1. ^ Wishka, D.; Walker, D.; Yates, K.; Reitz, S.; Jia, S.; Myers, J.; Olson, K.; Jacobsen, E. et al. (2006). "Discovery of N-(3R)-1-azabicyclo2.2.2oct-3-ylfuro2,3-cpyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship". Journal of medicinal chemistry 49 (14): 4425–4436. doi:10.1021/jm0602413. PMID 16821801.  edit


Got something to say? Make a comment.
Your name
Your email address