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PHD finger protein 1
Symbols PHF1; PHF2
External IDs OMIM602881 MGI98647 HomoloGene7567 GeneCards: PHF1 Gene
RNA expression pattern
PBB GE PHF1 40446 at tn.png
PBB GE PHF1 202928 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5252 21652
Ensembl ENSG00000112511 ENSMUSG00000024193
UniProt O43189 Q9Z1B8
RefSeq (mRNA) NM_002636 XM_994575
RefSeq (protein) NP_002627 XP_999669
Location (UCSC) Chr 6:
33.49 - 33.49 Mb
Chr 17:
26.66 - 26.67 Mb
PubMed search [1] [2]

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]


  1. ^ Coulson M, Robert S, Eyre HJ, Saint R (Jun 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics 48 (3): 381-3. doi:10.1006/geno.1997.5201. PMID 9545646.  
  2. ^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Res 36 (9): 2939-47. doi:10.1093/nar/gkn146. PMID 18385154.  
  3. ^ a b "Entrez Gene: PHF1 PHD finger protein 1".  

Further reading

  • Cao R, Wang H, He J, et al. (2008). "Role of hPHF1 in H3K27 methylation and Hox gene silencing.". Mol. Cell. Biol. 28 (5): 1862–72. doi:10.1128/MCB.01589-07. PMID 18086877.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • O'Connell S, Wang L, Robert S, et al. (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.". J. Biol. Chem. 276 (46): 43065–73. doi:10.1074/jbc.M104294200. PMID 11571280.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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