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PHD finger protein 16
Symbols PHF16; KIAA0215; JADE3; MGC138748; MGC138749
External IDs OMIM300618 MGI2148019 HomoloGene40981 GeneCards: PHF16 Gene
RNA expression pattern
PBB GE PHF16 204866 at tn.png
More reference expression data
Species Human Mouse
Entrez 9767 382207
Ensembl ENSG00000102221 ENSMUSG00000037315
UniProt Q92613 Q6IE82
RefSeq (mRNA) NM_001077445 NM_199317
RefSeq (protein) NP_001070913 NP_955021
Location (UCSC) Chr X:
46.66 - 46.81 Mb
Chr X:
19.58 - 19.68 Mb
PubMed search [1] [2]

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.[1][2]

This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.[2]


  1. ^ Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (Apr 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics 79 (4): 560-72. doi:10.1006/geno.2002.6733. PMID 11944989.  
  2. ^ a b "Entrez Gene: PHF16 PHD finger protein 16".  

Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.  
  • Szelei J, Soto AM, Geck P, et al. (2000). "Identification of human estrogen-inducible transcripts that potentially mediate the apoptotic response in breast cancer.". J. Steroid Biochem. Mol. Biol. 72 (3-4): 89–102. doi:10.1016/S0960-0760(00)00025-X. PMID 10775800.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tzouanacou E, Tweedie S, Wilson V (2003). "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.". Mol. Cell. Biol. 23 (23): 8553–2. doi:10.1128/MCB.23.23.8553-8562.2003. PMID 14612400.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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