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PHF17: Wikis


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PHD finger protein 17
Symbols PHF17; FLJ22479; JADE1; KIAA1807
External IDs OMIM610514 MGI1925835 HomoloGene18162 GeneCards: PHF17 Gene
RNA expression pattern
PBB GE PHF17 218517 at tn.png
PBB GE PHF17 gnf1h01443 s at tn.png
PBB GE PHF17 gnf1h09361 s at tn.png
More reference expression data
Species Human Mouse
Entrez 79960 269424
Ensembl ENSG00000077684 ENSMUSG00000025764
UniProt Q6IE81 Q6UZ80
RefSeq (mRNA) NM_024900 NM_172303
RefSeq (protein) NP_079176 NP_758507
Location (UCSC) Chr 4:
129.97 - 130.01 Mb
Chr 3:
41.65 - 41.71 Mb
PubMed search [1] [2]

Protein Jade-1 is a protein that in humans is encoded by the PHF17 gene.[1][2][3]



PHF17 has been shown to interact with Beta-catenin[4] and Von Hippel-Lindau tumor suppressor.[2]


  1. ^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 8 (2): 85–95. PMID 11347906.  
  2. ^ a b Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT (Oct 2002). "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". J Biol Chem 277 (42): 39887–98. doi:10.1074/jbc.M205040200. PMID 12169691.  
  3. ^ "Entrez Gene: PHF17 PHD finger protein 17".  
  4. ^ Chitalia, Vipul C; Foy Rebecca L, Bachschmid Markus M, Zeng Liling, Panchenko Maria V, Zhou Mina I, Bharti Ajit, Seldin David C, Lecker Stewart H, Dominguez Isabel, Cohen Herbert T (Oct. 2008). "Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL". Nat. Cell Biol. (England) 10 (10): 1208–16. doi:10.1038/ncb1781. PMID 18830218.  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tzouanacou E, Tweedie S, Wilson V (2003). "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.". Mol. Cell. Biol. 23 (23): 8553–2. doi:10.1128/MCB.23.23.8553-8562.2003. PMID 14612400.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Panchenko MV, Zhou MI, Cohen HT (2005). "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity.". J. Biol. Chem. 279 (53): 56032–41. doi:10.1074/jbc.M410487200. PMID 15502158.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Zhou MI, Foy RL, Chitalia VC, et al. (2005). "Jade-1, a candidate renal tumor suppressor that promotes apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11035–40. doi:10.1073/pnas.0500757102. PMID 16046545.  
  • Doyon Y, Cayrou C, Ullah M, et al. (2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.". Mol. Cell 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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