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PHF21A: Wikis


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PHD finger protein 21A
Symbols PHF21A; BHC80; BM-006; KIAA1696
External IDs OMIM608325 HomoloGene9597 GeneCards: PHF21A Gene
RNA expression pattern
PBB GE PHF21A 203278 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51317 n/a
Ensembl ENSG00000135365 n/a
UniProt Q96BD5 n/a
RefSeq (mRNA) NM_016621 n/a
RefSeq (protein) NP_057705 n/a
Location (UCSC) Chr 11:
45.91 - 46.1 Mb
PubMed search [1] n/a

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]



PHF21A has been shown to interact with HMG20B,[2][4] HDAC1,[2][4] Histone deacetylase 2[2][4][5] and RCOR1.[2][4]


  1. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. PMID 11214970.  
  2. ^ a b c d e Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc Natl Acad Sci U S A 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMID 12032298.  
  3. ^ a b "Entrez Gene: PHF21A PHD finger protein 21A".  
  4. ^ a b c d Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi (Sep. 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. (United States) 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. ISSN 0006-291X. PMID 15325272.  
  5. ^ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb. 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763.  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Iwase S, Januma A, Miyamoto K, et al. (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Shi YJ, Matson C, Lan F, et al. (2005). "Regulation of LSD1 histone demethylase activity by its associated factors.". Mol. Cell 19 (6): 857–64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Hailesellasse Sene K, Porter CJ, Palidwor G, et al. (2007). "Gene function in early mouse embryonic stem cell differentiation.". BMC Genomics 8: 85. doi:10.1186/1471-2164-8-85. PMID 17394647.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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