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Protein inhibitor of activated STAT, 2
Identifiers
Symbols PIAS2; MGC102682; MIZ1; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4; miz
External IDs OMIM603567 MGI1096566 HomoloGene20979 GeneCards: PIAS2 Gene
RNA expression pattern
PBB GE PIAS2 37433 at tn.png
PBB GE PIAS2 214442 s at tn.png
PBB GE PIAS2 214593 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9063 17344
Ensembl ENSG00000078043 ENSMUSG00000025423
UniProt O75928 Q3V3U5
RefSeq (mRNA) XM_001129747 XM_990156
RefSeq (protein) XP_001129747 XP_995250
Location (UCSC) Chr 18:
42.65 - 42.75 Mb
Chr 18:
77.3 - 77.36 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.[1][2][3]

Interactions

Protein inhibitor of activated STAT2 has been shown to interact with Androgen receptor,[4][5] DNMT3A,[6] PARK7[7] and UBE2I.[8][9]

References

  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–31. PMID 9724754.  
  2. ^ Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (Sep 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech Dev 65 (1-2): 3–17. PMID 9256341.  
  3. ^ "Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9063.  
  4. ^ Kotaja, N; Aittomäki S, Silvennoinen O, Palvimo J J, Jänne O A (Dec. 2000). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. (United States) 14 (12): 1986–2000. ISSN 0888-8809. PMID 11117529.  
  5. ^ Moilanen, A M; Karvonen U, Poukka H, Yan W, Toppari J, Jänne O A, Palvimo J J (Feb. 1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". J. Biol. Chem. (UNITED STATES) 274 (6): 3700–4. ISSN 0021-9258. PMID 9920921.  
  6. ^ Ling, Yan; Sankpal Umesh T, Robertson Andrea K, McNally James G, Karpova Tatiana, Robertson Keith D (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. (England) 32 (2): 598–610. doi:10.1093/nar/gkh195. PMID 14752048.  
  7. ^ Takahashi, K; Taira T, Niki T, Seino C, Iguchi-Ariga S M, Ariga H (Oct. 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. (United States) 276 (40): 37556–63. doi:10.1074/jbc.M101730200. ISSN 0021-9258. PMID 11477070.  
  8. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  9. ^ Lee, Byoung-Hee; Yoshimatsu Kumiko, Maeda Akihiko, Ochiai Kazuhiko, Morimatsu Masami, Araki Koichi, Ogino Michiko, Morikawa Shigeru, Arikawa Jiro (Dec. 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. (Netherlands) 98 (1): 83–91. ISSN 0168-1702. PMID 14609633.  

Further reading

  • Cookson MR (2003). "Pathways to Parkinsonism.". Neuron 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767.  
  • Moilanen AM, Karvonen U, Poukka H, et al. (1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.". J. Biol. Chem. 274 (6): 3700–4. doi:10.1074/jbc.274.6.3700. PMID 9920921.  
  • Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.  
  • Kotaja N, Aittomäki S, Silvennoinen O, et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.". Mol. Endocrinol. 14 (12): 1986–2000. doi:10.1210/me.14.12.1986. PMID 11117529.  
  • Gross M, Liu B, Tan J, et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.". Oncogene 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351.  
  • Takahashi K, Taira T, Niki T, et al. (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.  
  • Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872–7. doi:10.1073/pnas.052559499. PMID 11867732.  
  • Tan JA, Hall SH, Hamil KG, et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.  
  • Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.". J. Biol. Chem. 277 (44): 41311–7. doi:10.1074/jbc.M206741200. PMID 12177000.  
  • Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I.". J. Biol. Chem. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.  
  • Tussié-Luna MI, Bayarsaihan D, Seto E, et al. (2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12807–12. doi:10.1073/pnas.192464499. PMID 12239342.  
  • Miyauchi Y, Yogosawa S, Honda R, et al. (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.". J. Biol. Chem. 277 (51): 50131–6. doi:10.1074/jbc.M208319200. PMID 12393906.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Arora T, Liu B, He H, et al. (2003). "PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.". J. Biol. Chem. 278 (24): 21327–30. doi:10.1074/jbc.C300119200. PMID 12716907.  
  • Ohshima T, Shimotohno K (2004). "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4.". J. Biol. Chem. 278 (51): 50833–42. doi:10.1074/jbc.M307533200. PMID 14514699.  
  • Lee BH, Yoshimatsu K, Maeda A, et al. (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.  
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.  
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