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PIAS4: Wikis


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Protein inhibitor of activated STAT, 4
Symbols PIAS4; FLJ12419; MGC35296; PIASY; Piasg; ZMIZ6
External IDs OMIM605989 MGI2136940 HomoloGene41071 GeneCards: PIAS4 Gene
RNA expression pattern
PBB GE PIAS4 212881 at tn.png
PBB GE PIAS4 212879 x at tn.png
More reference expression data
Species Human Mouse
Entrez 51588 59004
Ensembl ENSG00000105229 ENSMUSG00000004934
UniProt Q8N2W9 Q3UGQ2
RefSeq (mRNA) NM_015897 NM_021501
RefSeq (protein) NP_056981 NP_067476
Location (UCSC) Chr 19:
3.96 - 3.99 Mb
Chr 10:
80.56 - 80.57 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS4 is an enzyme that in humans is encoded by the PIAS4 gene.[1][2]


PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,[3] Mothers against decapentaplegic homolog 7[3] and Lymphoid enhancer-binding factor 1.[4]


  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–31. PMID 9724754.  
  2. ^ "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4".  
  3. ^ a b Imoto, Seiyu; Sugiyama Kenji, Muromoto Ryuta, Sato Noriko, Yamamoto Tetsuya, Matsuda Tadashi (Sep. 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. Chem. (United States) 278 (36): 34253–8. doi:10.1074/jbc.M304961200. ISSN 0021-9258. PMID 12815042.  
  4. ^ Sachdev, S; Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R (Dec. 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. (United States) 15 (23): 3088–103. ISSN 0890-9369. PMID 11731472.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Liu B, Gross M, ten Hoeve J, Shuai K (2001). "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3203–7. doi:10.1073/pnas.051489598. PMID 11248056.  
  • Nelson V, Davis GE, Maxwell SA (2001). "A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.". Apoptosis 6 (3): 221–34. doi:10.1023/A:1011392811628. PMID 11388671.  
  • Gross M, Liu B, Tan J, et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.". Oncogene 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351.  
  • Sachdev S, Bruhn L, Sieber H, et al. (2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.". Genes Dev. 15 (23): 3088–103. doi:10.1101/gad.944801. PMID 11731474.  
  • Ohmine K, Ota J, Ueda M, et al. (2002). "Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells.". Oncogene 20 (57): 8249–57. doi:10.1038/sj.onc.1205029. PMID 11781839.  
  • Tan JA, Hall SH, Hamil KG, et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Subramanian L, Benson MD, Iñiguez-Lluhí JA (2003). "A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.". J. Biol. Chem. 278 (11): 9134–41. doi:10.1074/jbc.M210440200. PMID 12511558.  
  • Dahle Ø, Andersen TØ, Nordgård O, et al. (2003). "Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.". Eur. J. Biochem. 270 (6): 1338–48. doi:10.1046/j.1432-1033.2003.03504.x. PMID 12631292.  
  • Yamamoto H, Ihara M, Matsuura Y, Kikuchi A (2003). "Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.". Embo J. 22 (9): 2047–59. doi:10.1093/emboj/cdg204. PMID 12727872.  
  • Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.". J. Biol. Chem. 278 (30): 27853–63. doi:10.1074/jbc.M301755200. PMID 12740389.  
  • Chun TH, Itoh H, Subramanian L, et al. (2003). "Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.". Circ. Res. 92 (11): 1201–8. doi:10.1161/01.RES.0000076893.70898.36. PMID 12750312.  
  • Imoto S, Sugiyama K, Muromoto R, et al. (2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.". J. Biol. Chem. 278 (36): 34253–8. doi:10.1074/jbc.M304961200. PMID 12815042.  
  • Galleguillos D, Vecchiola A, Fuentealba JA, et al. (2004). "PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.". J. Biol. Chem. 279 (3): 2005–11. doi:10.1074/jbc.M308113200. PMID 14559918.  
  • Gross M, Yang R, Top I, et al. (2004). "PIASy-mediated repression of the androgen receptor is independent of sumoylation.". Oncogene 23 (17): 3059–66. doi:10.1038/sj.onc.1207443. PMID 14981544.  
  • Zoumpoulidou G, Jones MC, Fernandez de Mattos S, et al. (2005). "Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y).". Mol. Endocrinol. 18 (8): 1988–99. doi:10.1210/me.2003-0467. PMID 15155784.  
  • Imoto S, Sugiyama K, Yamamoto T, Matsuda T (2004). "The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.". Biochem. Biophys. Res. Commun. 319 (1): 275–82. doi:10.1016/j.bbrc.2004.04.161. PMID 15158472.  


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