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PNU-22394: Wikis

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PNU-22394
Systematic (IUPAC) name
6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole
Identifiers
CAS number 15923-78-1
ATC code  ?
PubChem 27559
Chemical data
Formula C 13H16N2  
Mol. mass 200.279 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B. It has anorectic effects in both animal studies and human trials, although it has never been developed for medical use.[1][2]

See also

References

  1. ^ McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.
  2. ^ Garfield AS, Heisler LK (January 2009). "Pharmacological targeting of the serotonergic system for the treatment of obesity". The Journal of Physiology 587 (Pt 1): 49–60. doi:10.1113/jphysiol.2008.164152. PMID 19029184.  
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