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PNU-282,987: Wikis

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PNU-282,987
Systematic (IUPAC) name
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide
Identifiers
CAS number 123464-89-1
ATC code  ?
PubChem 11243536
Chemical data
Formula C14H17ClN2O 
Mol. mass 264.750
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

PNU-282,987 is a drug which acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] In animal studies it shows nootropic effects and derivatives may be useful in the treatment of schizophrenia,[3][4] although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget.[5]

References

  1. ^ Hajós, M.; Hurst, R.; Hoffmann, W.; Krause, M.; Wall, T.; Higdon, N.; Groppi, V. (2005). "The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 N-(3R)-1-Azabicyclo2.2.2oct-3-yl-4-chlorobenzamide hydrochloride enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats". The Journal of pharmacology and experimental therapeutics 312 (3): 1213–1222. doi:10.1124/jpet.104.076968. PMID 15523001.  edit
  2. ^ Bodnar, A.; Cortes-Burgos, L.; Cook, K.; Dinh, D.; Groppi, V.; Hajos, M.; Higdon, N.; Hoffmann, W. et al. (2005). "Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors". Journal of medicinal chemistry 48 (4): 905–908. doi:10.1021/jm049363q. PMID 15715459.  edit
  3. ^ Hansen, H.; Timmermann, D.; Peters, D.; Walters, C.; Damaj, M.; Mikkelsen, J. (2007). "Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics". Journal of neuroscience research 85 (8): 1810–1818. doi:10.1002/jnr.21293. PMID 17455307.  edit
  4. ^ Redrobe, J. (2009). "Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice". European journal of pharmacology 602 (1): 58–65. doi:10.1016/j.ejphar.2008.09.035 PMID 18848931
  5. ^ Walker DP, Wishka DG, Piotrowski DW, et al. (2006). "Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists". Bioorg. Med. Chem. 14 (24): 8219–48. doi:10.1016/j.bmc.2006.09.019. PMID 17011782. 
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