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POU domain, class 2, transcription factor 3

PDB rendering based on 1pou.
Available structures
1pou
Identifiers
Symbols POU2F3; Epoc-1; FLJ40063; MGC126698; OCT11; PLA-1; Skn-1a
External IDs OMIM607394 MGI102565 HomoloGene7898 GeneCards: POU2F3 Gene
RNA expression pattern
PBB GE POU2F3 207109 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25833 18988
Ensembl ENSG00000137709 ENSMUSG00000032015
UniProt Q9UKI9 P70260
RefSeq (mRNA) NM_014352 NM_011139
RefSeq (protein) NP_055167 NP_035269
Location (UCSC) Chr 11:
119.62 - 119.7 Mb
Chr 9:
42.88 - 42.96 Mb
PubMed search [1] [2]

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.[1][2]

References

  1. ^ Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem 274 (37): 26399-406. PMID 10473598.  
  2. ^ "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25833.  

Further reading

  • Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMID 8441607.  
  • Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300.". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. PMID 12624109.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines.". Oncogene 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.  
  • Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression.". Placenta 27 (4-5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.  
  • Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer.". Oncogene 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.  
  • Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.  
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