The Full Wiki

More info on POU4F2

POU4F2: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

POU domain, class 4, transcription factor 2
Symbols POU4F2; BRN3.2; BRN3B; Brn-3b
External IDs OMIM113725 MGI102524 HomoloGene20959 GeneCards: POU4F2 Gene
RNA expression pattern
PBB GE POU4F2 207725 at tn.png
More reference expression data
Species Human Mouse
Entrez 5458 18997
Ensembl ENSG00000151615 ENSMUSG00000031688
UniProt Q12837 Q62091
RefSeq (mRNA) NM_004575 NM_138944
RefSeq (protein) NP_004566 NP_620394
Location (UCSC) Chr 4:
147.78 - 147.78 Mb
Chr 8:
81.33 - 81.33 Mb
PubMed search [1] [2]

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[1][2]

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][2]



POU4F2 has been shown to interact with Estrogen receptor alpha.[3]

See also


  1. ^ Ring CJ, Latchman DS (Aug 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Res 21 (12): 2946. PMID 8332509.  
  2. ^ a b "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".  
  3. ^ Budhram-Mahadeo, V; Parker M, Latchman D S (Feb. 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Mol. Cell. Biol. (UNITED STATES) 18 (2): 1029–41. ISSN 0270-7306. PMID 9448000.  

Further reading

  • Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.  
  • Xiang M, Zhou L, Peng YW, et al. (1993). "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.". Neuron 11 (4): 689–701. doi:10.1016/0896-6273(93)90079-7. PMID 7691107.  
  • Bhargava AK, Li Z, Weissman SM (1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10260–4. doi:10.1073/pnas.90.21.10260. PMID 8234287.  
  • Smith MD, Dawson SJ, Latchman DS (1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.". J. Biol. Chem. 272 (2): 1382–8. doi:10.1074/jbc.272.2.1382. PMID 8995448.  
  • Budhram-Mahadeo V, Parker M, Latchman DS (1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.". Mol. Cell. Biol. 18 (2): 1029–41. PMID 9448000.  
  • Dennis JH, Budhram-Mahadeo V, Latchman DS (2001). "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells.". Oncogene 20 (36): 4961–71. doi:10.1038/sj.onc.1204491. PMID 11526481.  
  • de Melo J, Qiu X, Du G, et al. (2003). "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina.". J. Comp. Neurol. 461 (2): 187–204. doi:10.1002/cne.10674. PMID 12724837.  
  • Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS (2004). "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.". Cancer Biol. Ther. 3 (3): 317–23. PMID 14726699.  
  • Irshad S, Pedley RB, Anderson J, et al. (2004). "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.". J. Biol. Chem. 279 (20): 21617–27. doi:10.1074/jbc.M312506200. PMID 14970234.  
  • Lee SA, Ndisang D, Patel C, et al. (2005). "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.". Cancer Res. 65 (8): 3072–80. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836.  
  • Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.". J. Mol. Neurosci. 26 (1): 17–25. doi:10.1385/JMN:26:1:017. PMID 15968082.  
  • Samady L, Faulkes DJ, Budhram-Mahadeo V, et al. (2006). "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.". Int. J. Cancer 118 (4): 869–78. doi:10.1002/ijc.21435. PMID 16152597.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.". Physiol. Genomics 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.  
  • Calissano M, Diss JK, Latchman DS (2007). "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells.". FEBS Lett. 581 (13): 2490–6. doi:10.1016/j.febslet.2007.04.066. PMID 17490655.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address